| Literature DB >> 19131243 |
Sock Teng Chua1, Ngee Mien Quek, Ming Li, Magdeline Tao Tao Ng, Weixing Yuan, May Ling Chua, Juanjuan Guo, Li Eng Koh, Ruijuan Ye, Tianhu Li.
Abstract
A series of oligonucleotides with various lengths that contain nick and topoisomerase I-binding sites were designed. The interactions between these oligonucleotides and human topoisomerase I were investigated and the most efficient one among them has displayed IC(50) value of 6.3 nM. Our studies have also demonstrated that the position of the nick as well as the length of the oligonucleotides were crucial factors for the inhibition of this nuclear enzyme.Entities:
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Year: 2008 PMID： 19131243 DOI： 10.1016/j.bmcl.2008.12.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823