Literature DB >> 19129776

Gamma-secretase inhibitors: Notch so bad.

Gerard C Grosveld.   

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Year:  2009        PMID： 19129776      PMCID： PMC2659646          DOI： 10.1038/nm0109-20

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


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  13 in total

1.  Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Authors:  Andrew P Weng; Adolfo A Ferrando; Woojoong Lee; John P Morris; Lewis B Silverman; Cheryll Sanchez-Irizarry; Stephen C Blacklow; A Thomas Look; Jon C Aster
Journal:  Science       Date:  2004-10-08       Impact factor: 47.728

Review 2.  Structure and function of gamma-secretase.

Authors:  Alexandra Tolia; Bart De Strooper
Journal:  Semin Cell Dev Biol       Date:  2008-11-01       Impact factor: 7.727

3.  Signaling pathways involved in the development of T-cell acute lymphoblastic leukemia.

Authors:  Frank J T Staal; Anton W Langerak
Journal:  Haematologica       Date:  2008-04       Impact factor: 9.941

4.  Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.

Authors:  J J Hsieh; T Henkel; P Salmon; E Robey; M G Peterson; S D Hayward
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

5.  Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

Authors:  Mark Y Chiang; Lanwei Xu; Olga Shestova; Gavin Histen; Sarah L'heureux; Candice Romany; M Eden Childs; Phyllis A Gimotty; Jon C Aster; Warren S Pear
Journal:  J Clin Invest       Date:  2008-09       Impact factor: 14.808

6.  Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

Authors:  Joseph Milano; Jenny McKay; Claude Dagenais; Linda Foster-Brown; Francois Pognan; Reto Gadient; Robert T Jacobs; Anna Zacco; Barry Greenberg; Paul J Ciaccio
Journal:  Toxicol Sci       Date:  2004-08-19       Impact factor: 4.849

7.  Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.

Authors:  Adolfo A Ferrando; Donna S Neuberg; Jane Staunton; Mignon L Loh; Christine Huard; Susana C Raimondi; Fred G Behm; Ching Hon Pui; James R Downing; D Gary Gilliland; Eric S Lander; Todd R Golub; A Thomas Look
Journal:  Cancer Cell       Date:  2002-02       Impact factor: 31.743

8.  The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.

Authors:  Jonathan P Katz; Nathalie Perreault; Bree G Goldstein; Catherine S Lee; Patricia A Labosky; Vincent W Yang; Klaus H Kaestner
Journal:  Development       Date:  2002-06       Impact factor: 6.868

9.  Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

Authors:  W S Pear; J C Aster; M L Scott; R P Hasserjian; B Soffer; J Sklar; D Baltimore
Journal:  J Exp Med       Date:  1996-05-01       Impact factor: 14.307

10.  Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

Authors:  Pedro J Real; Valeria Tosello; Teresa Palomero; Mireia Castillo; Eva Hernando; Elisa de Stanchina; Maria Luisa Sulis; Kelly Barnes; Catherine Sawai; Irene Homminga; Jules Meijerink; Iannis Aifantis; Giuseppe Basso; Carlos Cordon-Cardo; Walden Ai; Adolfo Ferrando
Journal:  Nat Med       Date:  2008-12-21       Impact factor: 53.440
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  17 in total

1.  Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling.

Authors:  Michael J Mallory; Samuel J Allon; Jinsong Qiu; Matthew R Gazzara; Iulia Tapescu; Nicole M Martinez; Xiang-Dong Fu; Kristen W Lynch
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

Review 2.  Stem cells in gastrointestinal cancers: The road less travelled.

Authors:  Sameh Mikhail; Amer Zeidan
Journal:  World J Stem Cells       Date:  2014-11-26       Impact factor: 5.326

3.  Calcitonin Gene-Related Peptide Attenuates Hyperoxia-Induced Oxidative Damage in Alveolar Epithelial Type II Cells Through Regulating Viability and Transdifferentiation.

Authors:  Jian Deng; Shao-Hua Wang; Xue-Mei Zheng; Zan-Mei Tang
Journal:  Inflammation       Date:  2022-01-06       Impact factor: 4.092

4.  Alterations of the Notch pathway in lung cancer.

Authors:  Britta Westhoff; Ivan N Colaluca; Giovanni D'Ario; Maddalena Donzelli; Daniela Tosoni; Sara Volorio; Giuseppe Pelosi; Lorenzo Spaggiari; Giovanni Mazzarol; Giuseppe Viale; Salvatore Pece; Pier Paolo Di Fiore
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205

Review 5.  Stem cells and solid cancers.

Authors:  Stuart A C McDonald; Trevor A Graham; Stefanie Schier; Nicholas A Wright; Malcolm R Alison
Journal:  Virchows Arch       Date:  2009-06-05       Impact factor: 4.064

6.  Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.

Authors:  Wei Xu; April M Weissmiller; Joseph A White; Fang Fang; Xinyi Wang; Yiwen Wu; Matthew L Pearn; Xiaobei Zhao; Mariko Sawa; Shengdi Chen; Shermali Gunawardena; Jianqing Ding; William C Mobley; Chengbiao Wu
Journal:  J Clin Invest       Date:  2016-04-11       Impact factor: 14.808

Review 7.  Gastric cancer stem cells: therapeutic targets.

Authors:  Slavica Stojnev; Miljan Krstic; Ana Ristic-Petrovic; Vladisav Stefanovic; Takanori Hattori
Journal:  Gastric Cancer       Date:  2013-04-06       Impact factor: 7.370

Review 8.  Other targeted drugs in melanoma.

Authors:  María González-Cao; Jordi Rodón; Niki Karachaliou; Jesús Sánchez; Mariacarmela Santarpia; Santiago Viteri; Sara Pilotto; Cristina Teixidó; Aldo Riso; Rafael Rosell
Journal:  Ann Transl Med       Date:  2015-10

9.  The role of Irf6 in tooth epithelial invagination.

Authors:  James Blackburn; Atsushi Ohazama; Katsushige Kawasaki; Yoko Otsuka-Tanaka; Bigang Liu; Kenya Honda; Ryan B Rountree; Yinling Hu; Maiko Kawasaki; Walter Birchmeier; Ruth Schmidt-Ullrich; Akira Kinoshita; Brian C Schutte; Nigel L Hammond; Michael J Dixon; Paul T Sharpe
Journal:  Dev Biol       Date:  2012-02-14       Impact factor: 3.582

Review 10.  Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders.

Authors:  Alexandros Marios Sofias; Federica De Lorenzi; Quim Peña; Armin Azadkhah Shalmani; Mihael Vucur; Jiong-Wei Wang; Fabian Kiessling; Yang Shi; Lorena Consolino; Gert Storm; Twan Lammers
Journal:  Adv Drug Deliv Rev       Date:  2021-06-15       Impact factor: 15.470
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