Literature DB >> 19128975

In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates.

Mi Kyoung Kim1, Kwang-su Park, Woon-seok Yeo, Hyunah Choo, Youhoon Chong.   

Abstract

In order to discover a quercetin prodrug with improved bioavailability, we synthesized nine quercetin-amion acid conjugates and estimated their pharmacokinetic properties including water solubility, stability against chemical or enzymatic hydrolysis, and cell permeability. Among the synthesized quercetin prodrugs, quercetin-glutamic acid conjugate Qu-E (4g/5g) showed remarkable increases in water solubility, stability, and cell permeability compared with quercetin, which warrants further development as a quercetin prodrug.

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Year:  2008        PMID： 19128975     DOI： 10.1016/j.bmc.2008.12.043

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.

Authors:  Samaa Alrushaid; Yunqi Zhao; Casey L Sayre; Zaid H Maayah; M Laird Forrest; Sanjeewa N Senadheera; Kevin Chaboyer; Hope D Anderson; Ayman O S El-Kadi; Neal M Davies
Journal:  Drug Deliv Transl Res       Date:  2017-08       Impact factor: 4.617

2.  Quercetin inhibits rhinovirus replication in vitro and in vivo.

Authors:  Shyamala Ganesan; Andrea N Faris; Adam T Comstock; Qiong Wang; Suparna Nanua; Marc B Hershenson; Uma S Sajjan
Journal:  Antiviral Res       Date:  2012-03-23       Impact factor: 5.970

3.  Amino Acid Carbamates As Prodrugs Of Resveratrol.

Authors:  Andrea Mattarei; Michele Azzolini; Martina La Spina; Mario Zoratti; Cristina Paradisi; Lucia Biasutto
Journal:  Sci Rep       Date:  2015-10-14       Impact factor: 4.379

4.  Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.

Authors:  Lenka Roubalová; David Biedermann; Barbora Papoušková; Jan Vacek; Marek Kuzma; Vladimír Křen; Jitka Ulrichová; Albena T Dinkova-Kostova; Jiří Vrba
Journal:  Chem Biol Interact       Date:  2016-10-21       Impact factor: 5.192

5.  Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative.

Authors:  Ting Gu; Yue Zhong; Yu-Ting Lu; Ying Sun; Ze-Xi Dong; Wen-Yu Wu; Zhi-Hao Shi; Nian-Guang Li; Xin Xue; Fang Fang; He-Min Li; Yu-Ping Tang
Journal:  Molecules       Date:  2017-06-21       Impact factor: 4.411

Review 6.  Research Progress in the Modification of Quercetin Leading to Anticancer Agents.

Authors:  Alessandro Massi; Olga Bortolini; Daniele Ragno; Tatiana Bernardi; Gianni Sacchetti; Massimo Tacchini; Carmela De Risi
Journal:  Molecules       Date:  2017-07-29       Impact factor: 4.411

7.  Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis.

Authors:  Desheng Cai; Jinchai Qi; Yuqin Yang; Wenxi Zhang; Fei Zhou; Xiaohui Jia; Wenbo Guo; Xuemei Huang; Feng Gao; Hongshan Chen; Tong Li; Guoping Li; Penglong Wang; Yuzhong Zhang; Haimin Lei
Journal:  Molecules       Date:  2019-11-07       Impact factor: 4.411

8.  Efficient synthesis of readily water-soluble sulfonic Acid carbamates.

Authors:  Krzysztof R Idzik; Karsten Nödler; Tobias Licha
Journal:  Molecules       Date:  2015-04-16       Impact factor: 4.411

9.  Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats.

Authors:  Shiva Ebrahimpour; Abolghasem Esmaeili; Siamak Beheshti
Journal:  Int J Nanomedicine       Date:  2018-10-11

10.  Quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) increases Nrf2 expression via miR-27a mediation to prevent memory dysfunction in diabetic rats.

Authors:  Shiva Ebrahimpour; Seyedeh Bahar Shahidi; Mahnoosh Abbasi; Zahra Tavakoli; Abolghasem Esmaeili
Journal:  Sci Rep       Date:  2020-09-29       Impact factor: 4.379
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