Literature DB >> 191286

Cyclic nucleotide levels in the perfused rat heart subjected to hypoxia.

R Nesher, W F Robinson, L Gibb, S P Bishop, F A Kruger.   

Abstract

Isolated rat hearts were subjected to hypoxic perfusion on a recirculating Langendorff apparatus. Following a 30-min-period of aerobic stabilization the hearts were perfused for 30 min with media equilibrated with 84% N2, 12%O2 and 4% CO2. At the end of the hypoxic period myocardial concentrations of cyclic AMP and cyclic GMP were determined by radioimmunoassay. Exposure to hypoxia resulted in a significant increase in cyclic AMP (p less than 0.01) and a decrease in cyclic GMP (p less than 0.05) as compared to hearts perfused for 60 min with media gassed with 96% O2. 4% CO2.

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Year:  1977        PMID： 191286     DOI： 10.1007/bf02124074

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Role of anaerobic metabolism in the preservation of functional capacity and structure of anoxic myocardium.

Authors:  A M Weissler; F A Kruger; N Baba; D G Scarpelli; R F Leighton; J K Gallimore
Journal:  J Clin Invest       Date:  1968-02       Impact factor: 14.808

2.  The effect of intermittent hypoxia on RNA synthesis in the isolated rat heart.

Authors:  L Gibb; S P Bishop; R Nesher; W F Robinson; A J Berry; F A Kruger
Journal:  J Mol Cell Cardiol       Date:  1976-06       Impact factor: 5.000

3.  Effect of nuclear protein kinases on mammalian RNA synthesis.

Authors:  O J Martelo; J Hirsch
Journal:  Biochem Biophys Res Commun       Date:  1974-06-18       Impact factor: 3.575

4.  Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle.

Authors:  A Wollenberger; E B Babskii; E G Krause; S Genz; D Blohm; E V Bogdanova
Journal:  Biochem Biophys Res Commun       Date:  1973-11-16       Impact factor: 3.575

5.  Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart.

Authors:  W J George; R D Wilkerson; P J Kadowitz
Journal:  J Pharmacol Exp Ther       Date:  1973-01       Impact factor: 4.030

6.  Effect of acute cardiac overload on intramyocardial cyclic 3',5'-AMP: relation to prostaglandin synthesis.

Authors:  C J Limas; D Ragan; E D Freis
Journal:  Proc Soc Exp Biol Med       Date:  1974-10

7.  Adenyl cyclase activity and cyclic AMP in acute cardiac overload: a method for measuring cyclic AMP production based on ATP specific activity.

Authors:  S S Schreiber; I L Klein; M Oratz; M A Rothschild
Journal:  J Mol Cell Cardiol       Date:  1971-03       Impact factor: 5.000

8.  Glycolytic control mechanisms. II. Kinetics of intermediate changes during the aerobic-anoxic transition in perfused rat heart.

Authors:  J R Williamson
Journal:  J Biol Chem       Date:  1966-11-10       Impact factor: 5.157

9.  Ribonucleic acid (RNA) polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.

Authors:  K G Nair; T Umali; J Potts
Journal:  Am J Cardiol       Date:  1973-09-20       Impact factor: 2.778

10.  Cyclic adenosine monophosphate in bacteria.

Authors:  I Pastan; R Perlman
Journal:  Science       Date:  1970-07-24       Impact factor: 47.728
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  3 in total

1.  The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat.

Authors:  K A Kane; E J Morcillo-Sanchez; J R Parratt; I W Rodger; M Shahid
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

Review 2.  The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism.

Authors:  Javier Inserte; David Garcia-Dorado
Journal:  Br J Pharmacol       Date:  2015-03-16       Impact factor: 8.739

3.  An endogenous protectant effect of cardiac cyclic GMP against reperfusion-induced ventricular fibrillation in the rat heart.

Authors:  R Pabla; P Bland-Ward; P K Moore; M J Curtis
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739
  3 in total

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