| Literature DB >> 19127576 |
I-Hweii Amy Chen1, Hiroshi Mitsumoto, Jean P Vonsattel, Arthur P Hays.
Abstract
Amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis without definable biomarkers. The pathomechanism of motor neuron degeneration in ALS has yet to be elucidated. Here we present a case of limb-onset ALS, with autopsy findings of Bunina bodies and skein-like inclusions, as well as sarcoid granulomas predominating among motor neurons. The targeting of the motor neurons by the sarcoid inflammation raises questions regarding the role of cellular immunity in the pathomechanisms for ALS.Entities:
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Year: 2009 PMID: 19127576 PMCID: PMC2847417 DOI: 10.1002/mus.21159
Source DB: PubMed Journal: Muscle Nerve ISSN: 0148-639X Impact factor: 3.217