Literature DB >> 19122666

Collagen VI protects neurons against Abeta toxicity.

Jason S Cheng1, Dena B Dubal, Daniel H Kim, Justin Legleiter, Irene H Cheng, Gui-Qiu Yu, Ina Tesseur, Tony Wyss-Coray, Paolo Bonaldo, Lennart Mucke.   

Abstract

Amyloid-beta (Abeta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Abeta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Abeta oligomers with neurons, enhanced Abeta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.

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Year:  2009        PMID： 19122666      PMCID： PMC2812922          DOI： 10.1038/nn.2240

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  14 in total

1.  Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

Authors:  F Verrecchia; M L Chu; A Mauviel
Journal:  J Biol Chem       Date:  2001-03-08       Impact factor: 5.157

2.  Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

Authors:  D Beher; L Hesse; C L Masters; G Multhaup
Journal:  J Biol Chem       Date:  1996-01-19       Impact factor: 5.157

3.  High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

Authors:  L Mucke; E Masliah; G Q Yu; M Mallory; E M Rockenstein; G Tatsuno; K Hu; D Kholodenko; K Johnson-Wood; L McConlogue
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

4.  Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

Authors:  Pascale N Lacor; Maria C Buniel; Lei Chang; Sara J Fernandez; Yuesong Gong; Kirsten L Viola; Mary P Lambert; Pauline T Velasco; Eileen H Bigio; Caleb E Finch; Grant A Krafft; William L Klein
Journal:  J Neurosci       Date:  2004-11-10       Impact factor: 6.167

5.  Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

Authors:  A Lorenzo; M Yuan; Z Zhang; P A Paganetti; C Sturchler-Pierrat; M Staufenbiel; J Mautino; F S Vigo; B Sommer; B A Yankner
Journal:  Nat Neurosci       Date:  2000-05       Impact factor: 24.884

6.  Adult mouse astrocytes degrade amyloid-beta in vitro and in situ.

Authors:  Tony Wyss-Coray; John D Loike; Thomas C Brionne; Emily Lu; Roman Anankov; Fengrong Yan; Samuel C Silverstein; Jens Husemann
Journal:  Nat Med       Date:  2003-03-03       Impact factor: 53.440

7.  Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

Authors:  Jorge J Palop; Jeannie Chin; Nga Bien-Ly; Catherine Massaro; Bertrand Z Yeung; Gui-Qiu Yu; Lennart Mucke
Journal:  J Neurosci       Date:  2005-10-19       Impact factor: 6.167

8.  Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.

Authors:  Jorge J Palop; Jeannie Chin; Erik D Roberson; Jun Wang; Myo T Thwin; Nga Bien-Ly; Jong Yoo; Kaitlyn O Ho; Gui-Qiu Yu; Anatol Kreitzer; Steven Finkbeiner; Jeffrey L Noebels; Lennart Mucke
Journal:  Neuron       Date:  2007-09-06       Impact factor: 17.173

9.  Collagen VI deficiency induces early onset myopathy in the mouse: an animal model for Bethlem myopathy.

Authors:  P Bonaldo; P Braghetta; M Zanetti; S Piccolo; D Volpin; G M Bressan
Journal:  Hum Mol Genet       Date:  1998-12       Impact factor: 6.150

10.  Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency.

Authors:  William A Irwin; Natascha Bergamin; Patrizia Sabatelli; Carlo Reggiani; Aram Megighian; Luciano Merlini; Paola Braghetta; Marta Columbaro; Dino Volpin; Giorgio M Bressan; Paolo Bernardi; Paolo Bonaldo
Journal:  Nat Genet       Date:  2003-11-16       Impact factor: 38.330
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  55 in total

1.  Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Authors:  Hairong Dong; Mila Blaivas; Michael M Wang
Journal:  Brain Res       Date:  2012-03-23       Impact factor: 3.252

2.  Interruptions in the collagen repeating tripeptide pattern can promote supramolecular association.

Authors:  Eileen S Hwang; Geetha Thiagarajan; Avanish S Parmar; Barbara Brodsky
Journal:  Protein Sci       Date:  2010-05       Impact factor: 6.725

Review 3.  The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.

Authors:  Gerwyn Morris; Ken Walder; Basant K Puri; Michael Berk; Michael Maes
Journal:  Mol Neurobiol       Date:  2015-08-27       Impact factor: 5.590

Review 4.  The collagen family.

Authors:  Sylvie Ricard-Blum
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-01-01       Impact factor: 10.005

5.  Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders.

Authors:  Sébastien S Hébert
Journal:  Cardiovasc Psychiatry Neurol       Date:  2009-08-24

6.  C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes.

Authors:  Stefanie Elisabeth Heumüller; Maya Talantikite; Manon Napoli; Jean Armengaud; Matthias Mörgelin; Ursula Hartmann; Gerhard Sengle; Mats Paulsson; Catherine Moali; Raimund Wagener
Journal:  J Biol Chem       Date:  2019-07-25       Impact factor: 5.157

Review 7.  Alzheimer mechanisms and therapeutic strategies.

Authors:  Yadong Huang; Lennart Mucke
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

8.  Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers.

Authors:  Matthew A Lalli; Gloria Garcia; Lucia Madrigal; Mauricio Arcos-Burgos; Mary Luz Arcila; Kenneth S Kosik; Francisco Lopera
Journal:  Hum Mutat       Date:  2012-08-10       Impact factor: 4.878

9.  A peptide study of the relationship between the collagen triple-helix and amyloid.

Authors:  Avanish S Parmar; Ana Monica Nunes; Jean Baum; Barbara Brodsky
Journal:  Biopolymers       Date:  2012-10       Impact factor: 2.505

10.  C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.

Authors:  Marie E Benoit; Michael X Hernandez; Minhan L Dinh; Francisca Benavente; Osvaldo Vasquez; Andrea J Tenner
Journal:  J Biol Chem       Date:  2012-11-13       Impact factor: 5.157
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