Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.

Literature DB >> 19122656

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.

Magdalena Sarasin-Filipowicz¹, Jacek Krol, Ilona Markiewicz, Markus H Heim, Witold Filipowicz.

Abstract

Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19122656 DOI： 10.1038/nm.1902

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

11 in total

1. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.

Authors: Catherine L Jopling; Minkyung Yi; Alissa M Lancaster; Stanley M Lemon; Peter Sarnow
Journal: Science Date: 2005-09-02 Impact factor: 47.728

2. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.

Authors: Brian D Brown; Bernhard Gentner; Alessio Cantore; Silvia Colleoni; Mario Amendola; Anna Zingale; Alessia Baccarini; Giovanna Lazzari; Cesare Galli; Luigi Naldini
Journal: Nat Biotechnol Date: 2007-11-16 Impact factor: 54.908

3. LNA-mediated microRNA silencing in non-human primates.

Authors: Joacim Elmén; Morten Lindow; Sylvia Schütz; Matthew Lawrence; Andreas Petri; Susanna Obad; Marie Lindholm; Maj Hedtjärn; Henrik Frydenlund Hansen; Urs Berger; Steven Gullans; Phil Kearney; Peter Sarnow; Ellen Marie Straarup; Sakari Kauppinen
Journal: Nature Date: 2008-03-26 Impact factor: 49.962

4. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection.

Authors: Limin Chen; Ivan Borozan; Jordan Feld; Jing Sun; Laura-Lee Tannis; Catalina Coltescu; Jenny Heathcote; Aled M Edwards; Ian D McGilvray
Journal: Gastroenterology Date: 2005-05 Impact factor: 22.682

5. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial.

Authors: M P Manns; J G McHutchison; S C Gordon; V K Rustgi; M Shiffman; R Reindollar; Z D Goodman; K Koury; M Ling; J K Albrecht
Journal: Lancet Date: 2001-09-22 Impact factor: 79.321

6. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C.

Authors: T Asselah; I Bieche; S Narguet; A Sabbagh; I Laurendeau; M-P Ripault; N Boyer; M Martinot-Peignoux; D Valla; M Vidaud; P Marcellin
Journal: Gut Date: 2007-09-25 Impact factor: 23.059

7. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.

Authors: Michael W Fried; Mitchell L Shiffman; K Rajender Reddy; Coleman Smith; George Marinos; Fernando L Gonçales; Dieter Häussinger; Moises Diago; Giampiero Carosi; Daniel Dhumeaux; Antonio Craxi; Amy Lin; Joseph Hoffman; Jian Yu
Journal: N Engl J Med Date: 2002-09-26 Impact factor: 91.245

8. Interferon modulation of cellular microRNAs as an antiviral mechanism.

Authors: Irene M Pedersen; Guofeng Cheng; Stefan Wieland; Stefano Volinia; Carlo M Croce; Francis V Chisari; Michael David
Journal: Nature Date: 2007-10-18 Impact factor: 49.962

9. Cellular cofactors affecting hepatitis C virus infection and replication.

Authors: Glenn Randall; Maryline Panis; Jacob D Cooper; Timothy L Tellinghuisen; Karen E Sukhodolets; Sebastien Pfeffer; Markus Landthaler; Pablo Landgraf; Sherry Kan; Brett D Lindenbach; Minchen Chien; David B Weir; James J Russo; Jingyue Ju; Michael J Brownstein; Robert Sheridan; Chris Sander; Mihaela Zavolan; Thomas Tuschl; Charles M Rice
Journal: Proc Natl Acad Sci U S A Date: 2007-07-06 Impact factor: 11.205

10. miRBase: tools for microRNA genomics.

Authors: Sam Griffiths-Jones; Harpreet Kaur Saini; Stijn van Dongen; Anton J Enright
Journal: Nucleic Acids Res Date: 2007-11-08 Impact factor: 16.971

125 in total

Review 1. The role of nuclear factor κB in the interferon response.

Authors: Lawrence M Pfeffer
Journal: J Interferon Cytokine Res Date: 2011-06-01 Impact factor: 2.607

2. Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development.

Authors: Hua Jia Diao; Wei Ching Low; Q Richard Lu; Sing Yian Chew
Journal: Biomaterials Date: 2015-08-18 Impact factor: 12.479

Review 3. MicroRNAs and liver disease.

Authors: Thomas A Kerr; Kevin M Korenblat; Nicholas O Davidson
Journal: Transl Res Date: 2011-02-02 Impact factor: 7.012

Review 4. Adenosine deaminases acting on RNA, RNA editing, and interferon action.

Authors: Cyril X George; Zhenji Gan; Yong Liu; Charles E Samuel
Journal: J Interferon Cytokine Res Date: 2010-12-23 Impact factor: 2.607

Review 5. Mechanisms of HCV survival in the host.

Authors: Ella H Sklan; Prista Charuworn; Philip S Pang; Jeffrey S Glenn
Journal: Nat Rev Gastroenterol Hepatol Date: 2009-04 Impact factor: 46.802

6. Reply to miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection.

Authors: Markus Heim
Journal: Nat Rev Immunol Date: 2013-12 Impact factor: 53.106

7. Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion.

Authors: Changfei Li; Yanzhong Wang; Saifeng Wang; Bo Wu; Junli Hao; Hongxia Fan; Ying Ju; Yuping Ding; Lizhao Chen; Xiaoyu Chu; Wenjun Liu; Xin Ye; Songdong Meng
Journal: J Virol Date: 2012-12-05 Impact factor: 5.103