Timothy G Dinan1. 1. Department of Psychiatry and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. t.dinan@ucc.ie
Abstract
PURPOSE OF REVIEW: To provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease. RECENT FINDINGS: The current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-alpha. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events. SUMMARY: Depression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.
PURPOSE OF REVIEW: To provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease. RECENT FINDINGS: The current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-alpha. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events. SUMMARY:Depression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.
Authors: Carol M Greco; Tracy Li; Abdus Sattar; Amy H Kao; Natalya Danchenko; Daniel Edmundowicz; Kim Sutton-Tyrrell; Russell P Tracy; Lewis H Kuller; Susan Manzi Journal: J Rheumatol Date: 2011-12-15 Impact factor: 4.666
Authors: Zuleide M Ignácio; Renato S da Silva; Marcos E Plissari; João Quevedo; Gislaine Z Réus Journal: Mol Neurobiol Date: 2019-06-21 Impact factor: 5.590
Authors: Álvaro Camacho; Britta Larsen; Robyn L McClelland; Cindy Morgan; Michael H Criqui; Mary Cushman; Matthew A Allison Journal: J Affect Disord Date: 2014-04-19 Impact factor: 4.839
Authors: Katarzyna Nazimek; Michael Kozlowski; Pawel Bryniarski; Spencer Strobel; Agata Bryk; Michal Myszka; Anna Tyszka; Piotr Kuszmiersz; Jaroslaw Nowakowski; Iwona Filipczak-Bryniarska Journal: Exp Biol Med (Maywood) Date: 2016-04-05
Authors: Rita Rastogi Kalyani; Nan Ji; Mercedes Carnethon; Alain G Bertoni; Elizabeth Selvin; Edward W Gregg; Mario Sims; Sherita Hill Golden Journal: J Diabetes Complications Date: 2017-03-09 Impact factor: 2.852