| Literature DB >> 19122315 |
Mamoru Kaname1, Masae Yamada, Shigeyuki Yoshifuji, Haruki Sashida.
Abstract
The short-step synthesis of the unsubstituted, 5-hydroxy- and 5-chloropiperidazine-3-carboxylic acids using an aza Diels-Alder reaction between the 1,3-diene and azodicarboxylate was described. This synthetic methodology could be used for the preparation of the optically active piperazic acid in a 35% overall yield.Entities:
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Year: 2009 PMID： 19122315 DOI： 10.1248/cpb.57.49
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645