Literature DB >> 19121314

Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells.

Zhaofeng Zhang1, Ming Zhao, Qiong Li, Haifeng Zhao, Junbo Wang, Yong Li.   

Abstract

In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in rat L6 cells. TNF-alpha downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-alpha-induced insulin resistance through AMPK pathway in skeletal muscle cells.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19121314     DOI： 10.1016/j.febslet.2008.12.053

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats.

Authors:  Masataka Suwa; Hiroshi Nakano; Zsolt Radak; Shuzo Kumagai
Journal:  J Physiol Sci       Date:  2014-11-12       Impact factor: 2.781

Review 2.  Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia.

Authors:  John M Lawler; Allyson Hindle
Journal:  Antioxid Redox Signal       Date:  2011-08-08       Impact factor: 8.401

3.  TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin.

Authors:  Erica D Louden; Kerri M Luzzo; Patricia T Jimenez; Tiffany Chi; Maggie Chi; Kelle H Moley
Journal:  Reprod Fertil Dev       Date:  2014-12       Impact factor: 2.311

4.  Multi-Omics Integration Analysis Identifies Lipid Disorder of a Non-Alcoholic Fatty Liver Disease (NAFLD) Mouse Model Improved by Zexie-Baizhu Decoction.

Authors:  Yuhan Cao; Jingying Shi; Luyao Song; Junjiu Xu; Henglei Lu; Jianhua Sun; Jinjun Hou; Jing Chen; Wanying Wu; Likun Gong
Journal:  Front Pharmacol       Date:  2022-06-20       Impact factor: 5.988

5.  Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation.

Authors:  Rainer Lehmann; Xinjie Zhao; Cora Weigert; Perikles Simon; Elvira Fehrenbach; Jens Fritsche; Jürgen Machann; Fritz Schick; Jiangshan Wang; Miriam Hoene; Erwin D Schleicher; Hans-Ulrich Häring; Guowang Xu; Andreas M Niess
Journal:  PLoS One       Date:  2010-07-12       Impact factor: 3.240

6.  Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II.

Authors:  Daniela Macconi; Luca Perico; Lorena Longaretti; Marina Morigi; Paola Cassis; Simona Buelli; Norberto Perico; Giuseppe Remuzzi; Ariela Benigni
Journal:  PLoS One       Date:  2015-05-19       Impact factor: 3.240

7.  Somatic mutation patterns and compound response in cancers.

Authors:  Ningning He; Nayoung Kim; Sukjoon Yoon
Journal:  BMB Rep       Date:  2013-02       Impact factor: 4.778

8.  Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-κB in C2C12 myotubes.

Authors:  Ming Zhao; Zhao-Feng Zhang; Ye Ding; Jun-Bo Wang; Yong Li
Journal:  Molecules       Date:  2012-06-11       Impact factor: 4.411

9.  Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial.

Authors:  Ali Dadrass; Khalid Mohamadzadeh Salamat; Kamaladdin Hamidi; Kamal Azizbeigi
Journal:  J Diabetes Metab Disord       Date:  2019-06-24

10.  Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies.

Authors:  Denisa Baci; Antonino Bruno; Caterina Cascini; Matteo Gallazzi; Lorenzo Mortara; Fausto Sessa; Giuseppe Pelosi; Adriana Albini; Douglas M Noonan
Journal:  J Exp Clin Cancer Res       Date:  2019-11-12
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.