Literature DB >> 19120103

Serotonergic changes produced by repeated exposure to forced swimming: correlation with behavior.

Galina T Shishkina1, Tatyana S Kalinina, Nikolay N Dygalo.   

Abstract

Repeated forced swim resulted in a decrease in the concentrations of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid in the hypothalamus and amygdala 24 h after the second swim session. This stressor also increased the mRNA levels for tryptophan hydroxylase-2, the rate-limiting enzyme in neuronal 5-HT synthesis, and 5-HT transporter in the midbrain as well as 5-HT1A receptor in the frontal cortex. Some of these serotonergic changes may be involved in the mechanisms of a depressive-like behavior induced by a stress of repeated swim in these animals.

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Year:  2008        PMID： 19120103     DOI： 10.1196/annals.1410.074

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  14 in total

Review 1.  Increased expression of the anti-apoptotic protein Bcl-xL in the brain is associated with resilience to stress-induced depression-like behavior.

Authors:  Nikolay N Dygalo; Tatyana S Kalinina; Veta V Bulygina; Galina T Shishkina
Journal:  Cell Mol Neurobiol       Date:  2012-01-26       Impact factor: 5.046

2.  BDNF protein expression in the hippocampus following exposure of rats to forced swimming stress.

Authors:  V V Bulygina; G T Shishkina; I V Berezova; N N Dygalo
Journal:  Dokl Biol Sci       Date:  2011-05-12

3.  Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders.

Authors:  Guo-Lin Chen; Gregory M Miller
Journal:  Biochem Pharmacol       Date:  2013-02-19       Impact factor: 5.858

Review 4.  Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.

Authors:  Guo-Lin Chen; Gregory M Miller
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-03       Impact factor: 3.568

5.  Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus.

Authors:  J W Lunden; L G Kirby
Journal:  Neuroscience       Date:  2013-09-20       Impact factor: 3.590

6.  Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex.

Authors:  Niamh Kieran; Xiao-Ming Ou; Abiye H Iyo
Journal:  Neurosci Lett       Date:  2009-12-18       Impact factor: 3.046

7.  Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses.

Authors:  Julia C Lemos; Guojun Zhang; Teresa Walsh; Lynn G Kirby; Adaure Akanwa; Amy Brooks-Kayal; Sheryl G Beck
Journal:  Neuropsychopharmacology       Date:  2010-12-15       Impact factor: 7.853

8.  Effects of swim stress and fluoxetine on 5-HT1A receptor gene expression and monoamine metabolism in the rat brain regions.

Authors:  G T Shishkina; T S Kalinina; N N Dygalo
Journal:  Cell Mol Neurobiol       Date:  2012-03-29       Impact factor: 5.046

9.  Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress.

Authors:  A H Iyo; N Kieran; A Chandran; P R Albert; I Wicks; G Bissette; M C Austin
Journal:  Neuroscience       Date:  2009-07-30       Impact factor: 3.590

Review 10.  Molecular, Functional, and Structural Imaging of Major Depressive Disorder.

Authors:  Kai Zhang; Yunqi Zhu; Yuankai Zhu; Shuang Wu; Hao Liu; Wei Zhang; Caiyun Xu; Hong Zhang; Takuya Hayashi; Mei Tian
Journal:  Neurosci Bull       Date:  2016-05-03       Impact factor: 5.203
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