| Literature DB >> 19118477 |
Mercedes Amat1, Robert Fabregat, Rosa Griera, Joan Bosch.
Abstract
A practical synthetic route to enantiopure 5-substituted cis-decahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of 2-substituted 6-oxocyclohexenepropionates 2 with (R)-phenylglycinol, the stereoselective hydrogenation of the resulting unsaturated tricyclic lactams, and the stereoselective reductive cleavage of the oxazolidine ring.Entities:
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Year: 2009 PMID： 19118477 DOI： 10.1021/jo802587h
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354