PURPOSE: Peripheral T-cell lymphoma, unspecified (PTCL-U) comprises histopathologically and clinically heterogeneous groups. The purpose of this study was to identify subgroups with distinct genetic, histopathologic, and prognostic features. EXPERIMENTAL DESIGN: We used array comparative genomic hybridization (CGH) for high-resolution analysis of 51 PTCL-U patients and the array data for examining possible correlations of histopathologic and clinical features. Moreover, we compared the genetic, histopathologic, and prognostic features of the PTCL-U cases with those of 59 cases of lymphoma-type adult T-cell leukemia/lymphoma (ATLL). RESULTS: We identified 32 regions with frequent genomic imbalance, 1 region with high copy number gain at 14q32.2, and 1 region with homozygous loss at 9p21.3. Gains of 7p and 7q and loss of 9p21.3 showed a significant association with poor prognosis. PTCL-U cases with genomic imbalance showed distinct histopathologic and prognostic features compared with such cases without alteration and a marked genetic, histopathologic, and prognostic resemblance to lymphoma-type ATLL. CONCLUSIONS: The array CGH enabled us to identify the frequently altered genomic regions with strong prognostic power among PTCL-U cases. A correlative analysis using the array CGH data disclosed a subgroup in PTCL-U with genomic alterations and with histopathologic and clinical relevance. In addition to histopathologic similarity, the strong genetic and prognostic resemblance between PTCL-U cases with genomic imbalance detected by array CGH and lymphoma-type ATLL seems to support the notion that the former may constitute a distinct PTCL-U subgroup.
PURPOSE: Peripheral T-cell lymphoma, unspecified (PTCL-U) comprises histopathologically and clinically heterogeneous groups. The purpose of this study was to identify subgroups with distinct genetic, histopathologic, and prognostic features. EXPERIMENTAL DESIGN: We used array comparative genomic hybridization (CGH) for high-resolution analysis of 51 PTCL-U patients and the array data for examining possible correlations of histopathologic and clinical features. Moreover, we compared the genetic, histopathologic, and prognostic features of the PTCL-U cases with those of 59 cases of lymphoma-type adult T-cell leukemia/lymphoma (ATLL). RESULTS: We identified 32 regions with frequent genomic imbalance, 1 region with high copy number gain at 14q32.2, and 1 region with homozygous loss at 9p21.3. Gains of 7p and 7q and loss of 9p21.3 showed a significant association with poor prognosis. PTCL-U cases with genomic imbalance showed distinct histopathologic and prognostic features compared with such cases without alteration and a marked genetic, histopathologic, and prognostic resemblance to lymphoma-type ATLL. CONCLUSIONS: The array CGH enabled us to identify the frequently altered genomic regions with strong prognostic power among PTCL-U cases. A correlative analysis using the array CGH data disclosed a subgroup in PTCL-U with genomic alterations and with histopathologic and clinical relevance. In addition to histopathologic similarity, the strong genetic and prognostic resemblance between PTCL-U cases with genomic imbalance detected by array CGH and lymphoma-type ATLL seems to support the notion that the former may constitute a distinct PTCL-U subgroup.
Authors: Rachael Thomas; Eric L Seiser; Alison Motsinger-Reif; Luke Borst; Victor E Valli; Kathryn Kelley; Steven E Suter; David Argyle; Kristine Burgess; Jerold Bell; Kerstin Lindblad-Toh; Jaime F Modiano; Matthew Breen Journal: Leuk Lymphoma Date: 2011-03-07
Authors: Tayla B Heavican; Alyssa Bouska; Jiayu Yu; Waseem Lone; Catalina Amador; Qiang Gong; Weiwei Zhang; Yuping Li; Bhavana J Dave; Maarja-Liisa Nairismägi; Timothy C Greiner; Julie Vose; Dennis D Weisenburger; Cynthia Lachel; Chao Wang; Kai Fu; Jadd M Stevens; Soon Thye Lim; Choon Kiat Ong; Randy D Gascoyne; Edoardo Missiaglia; Francois Lemonnier; Corinne Haioun; Sylvia Hartmann; Martin Bjerregård Pedersen; Maria Antonella Laginestra; Ryan A Wilcox; Bin Tean Teh; Noriaki Yoshida; Koichi Ohshima; Masao Seto; Andreas Rosenwald; German Ott; Elias Campo; Lisa M Rimsza; Elaine S Jaffe; Rita M Braziel; Francesco d'Amore; Giorgio Inghirami; Francesco Bertoni; Laurence de Leval; Philippe Gaulard; Louis M Staudt; Timothy W McKeithan; Stefano Pileri; Wing C Chan; Javeed Iqbal Journal: Blood Date: 2019-02-19 Impact factor: 22.113
Authors: Maja Ludvigsen; Martin Bjerregård Pedersen; Kristina Lystlund Lauridsen; Tim Svenstrup Poulsen; Stephen Jacques Hamilton-Dutoit; Søren Besenbacher; Knud Bendix; Michael Boe Møller; Peter Nørgaard; Francesco d'Amore; Bent Honoré Journal: Blood Adv Date: 2018-10-09