Literature DB >> 19117948

PTEN, stem cells, and cancer stem cells.

Reginald Hill1, Hong Wu.   

Abstract

Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with tumorigenesis. It has become clear recently that PTEN (phosphatase and tensin homologue) is also critical for stem cell maintenance and that PTEN loss can cause the development of cancer stem cells and ultimately tumorigenesis.

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Year:  2008        PMID： 19117948      PMCID： PMC2673242          DOI： 10.1074/jbc.R800071200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  50 in total

1.  Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.

Authors:  Shunyou Wang; Alejandro J Garcia; Michelle Wu; Devon A Lawson; Owen N Witte; Hong Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

2.  Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

Authors:  M Groszer; R Erickson; D D Scripture-Adams; R Lesche; A Trumpp; J A Zack; H I Kornblum; X Liu; H Wu
Journal:  Science       Date:  2001-11-01       Impact factor: 47.728

3.  High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.

Authors:  V Stambolic; M S Tsao; D Macpherson; A Suzuki; W B Chapman; T W Mak
Journal:  Cancer Res       Date:  2000-07-01       Impact factor: 12.701

Review 4.  Oncogenic PI3K and its role in cancer.

Authors:  Yardena Samuels; Kajsa Ericson
Journal:  Curr Opin Oncol       Date:  2006-01       Impact factor: 3.645

5.  Isolation of cancer stem cells from adult glioblastoma multiforme.

Authors:  Xiangpeng Yuan; James Curtin; Yizhi Xiong; Gentao Liu; Sebastian Waschsmann-Hogiu; Daniel L Farkas; Keith L Black; John S Yu
Journal:  Oncogene       Date:  2004-12-16       Impact factor: 9.867

6.  PTEN-deficient intestinal stem cells initiate intestinal polyposis.

Authors:  Xi C He; Tong Yin; Justin C Grindley; Qiang Tian; Toshiro Sato; W Andy Tao; Raminarao Dirisina; Kimberly S Porter-Westpfahl; Mark Hembree; Teri Johnson; Leanne M Wiedemann; Terrence A Barrett; Leroy Hood; Hong Wu; Linheng Li
Journal:  Nat Genet       Date:  2007-01-21       Impact factor: 38.330

7.  Identification of pancreatic cancer stem cells.

Authors:  Chenwei Li; David G Heidt; Piero Dalerba; Charles F Burant; Lanjing Zhang; Volkan Adsay; Max Wicha; Michael F Clarke; Diane M Simeone
Journal:  Cancer Res       Date:  2007-02-01       Impact factor: 12.701

8.  Pten is essential for embryonic development and tumour suppression.

Authors:  A Di Cristofano; B Pesce; C Cordon-Cardo; P P Pandolfi
Journal:  Nat Genet       Date:  1998-08       Impact factor: 38.330

9.  Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.

Authors:  Akira Suzuki; Satoshi Itami; Minako Ohishi; Koichi Hamada; Tae Inoue; Nobuyasu Komazawa; Haruki Senoo; Takehiko Sasaki; Junji Takeda; Motomu Manabe; Tak Wah Mak; Toru Nakano
Journal:  Cancer Res       Date:  2003-02-01       Impact factor: 12.701

10.  Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

Authors:  Shunyou Wang; Jing Gao; Qunying Lei; Nora Rozengurt; Colin Pritchard; Jing Jiao; George V Thomas; Gang Li; Pradip Roy-Burman; Peter S Nelson; Xin Liu; Hong Wu
Journal:  Cancer Cell       Date:  2003-09       Impact factor: 31.743
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  61 in total

Review 1.  [Tumor stem cell research - basis and challenge for diagnosis and therapy].

Authors:  Heidrun Karlic; Harald Herrmann; Axel Schulenburg; Thomas W Grunt; Sylvia Laffer; Irina Mirkina; Rainer Hubmann; Medhat Shehata; Brigitte Marian; Edgar Selzer; Michael Pfeilstöcker; Elisabeth Pittermann; Ulrich Jäger; Hubert Pehamberger; Christoph Zielinski; Peter Valent
Journal:  Wien Klin Wochenschr       Date:  2010-07-22       Impact factor: 1.704

2.  SLUG is a direct transcriptional repressor of PTEN tumor suppressor.

Authors:  Berna Uygur; Katrina Abramo; Evgenia Leikina; Calvin Vary; Lucy Liaw; Wen-Shu Wu
Journal:  Prostate       Date:  2015-03-01       Impact factor: 4.104

Review 3.  Cancer stem cells: progress and challenges in lung cancer.

Authors:  Amanda K Templeton; Shinya Miyamoto; Anish Babu; Anupama Munshi; Rajagopal Ramesh
Journal:  Stem Cell Investig       Date:  2014-04-15

Review 4.  The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase.

Authors:  Anyonya R Guntur; Clifford J Rosen
Journal:  J Endocrinol       Date:  2011-06-14       Impact factor: 4.286

5.  A genome-wide siRNA screen identifies novel phospho-enzymes affecting Wnt/β-catenin signaling in mouse embryonic stem cells.

Authors:  Jody Groenendyk; Marek Michalak
Journal:  Stem Cell Rev Rep       Date:  2011-11       Impact factor: 5.739

6.  VATER/VACTERL Association: Evidence for the Role of Genetic Factors.

Authors:  H Reutter; M Ludwig
Journal:  Mol Syndromol       Date:  2013-02

Review 7.  Therapies targeting cancer stem cells: Current trends and future challenges.

Authors:  Denisa L Dragu; Laura G Necula; Coralia Bleotu; Carmen C Diaconu; Mihaela Chivu-Economescu
Journal:  World J Stem Cells       Date:  2015-10-26       Impact factor: 5.326

8.  PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.

Authors:  Kostyantyn Krysan; Rebecca Kusko; Tristan Grogan; James O'Hearn; Karen L Reckamp; Tonya C Walser; Edward B Garon; Marc E Lenburg; Sherven Sharma; Avrum E Spira; David Elashoff; Steven M Dubinett
Journal:  Mol Cancer Res       Date:  2014-01-27       Impact factor: 5.852

9.  Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer.

Authors:  Vahid Haghpanah; Parviz Fallah; Rezvan Tavakoli; Mahmood Naderi; Hilda Samimi; Masoud Soleimani; Bagher Larijani
Journal:  Tumour Biol       Date:  2015-08-20

Review 10.  Redox regulation in cancer: a double-edged sword with therapeutic potential.

Authors:  Asha Acharya; Ila Das; Des Chandhok; Tapas Saha
Journal:  Oxid Med Cell Longev       Date:  2010 Jan-Feb       Impact factor: 6.543
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