| Literature DB >> 19117757 |
Jiang Jiang Qin1, Hui Zi Jin, Jian Jun Fu, Xiao Jia Hu, Yan Wang, Shi Kai Yan, Wei Dong Zhang.
Abstract
Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.Entities:
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Year: 2008 PMID： 19117757 DOI： 10.1016/j.bmcl.2008.12.043
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823