| Literature DB >> 19117548 |
Luoping Li1, Xin Xie, Jun Qin, George S Jeha, Pradip K Saha, Jun Yan, Claire M Haueter, Lawrence Chan, Sophia Y Tsai, Ming-Jer Tsai.
Abstract
Adipose tissue development and function play a central role in the pathogenesis and pathophysiology of metabolic syndromes. Here, we show that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) plays a pivotal role in adipogenesis and energy homeostasis. COUP-TFII is expressed in the early stages of white adipocyte development. COUP-TFII heterozygous mice (COUP-TFII(+/-)) have much less white adipose tissue (WAT) than wild-type mice (COUP-TFII(+/+)). COUP-TFII(+/-) mice display a decreased expression of key regulators for WAT development. Knockdown COUP-TFII in 3T3-L1 cells resulted in an increased expression of Wnt10b, while chromatin immunoprecipitation analysis revealed that Wnt10b is a direct target of COUP-TFII. Moreover, COUP-TFII(+/-) mice have increased mitochondrial biogenesis in WAT, and COUP-TFII(+/-) mice have improved glucose homeostasis and increased energy expenditure. Thus, COUP-TFII regulates adipogenesis by regulating the key molecules in adipocyte development and can serve as a target for regulating energy metabolism.Entities:
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Year: 2009 PMID： 19117548 PMCID： PMC2630393 DOI： 10.1016/j.cmet.2008.12.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287