Literature DB >> 19117476

Highly efficient and highly enantioselective asymmetric hydrogenation of ketones with TunesPhos/1,2-diamine-ruthenium(II) complexes.

Wei Li1, Xianfeng Sun, Le Zhou, Guohua Hou, Shichao Yu, Xumu Zhang.   

Abstract

The TunePhos/diamine-Ru(II) complex combined with t-BuOK in 2-propanol effectively catalyzes enantioselective hydrogenation of a wide range of simple ketones including aromatic, heteroaromatic, alpha,beta-unsaturated, and cyclopropyl ketones, affording high reactivity (up to 1,000,000 TON) and excellent enantioselectivities (>99% ee for 13 examples).

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Year:  2009        PMID： 19117476     DOI： 10.1021/jo802372w

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands.

Authors:  Ling Zhang; Qian Chen; Linlin Li; Jian Jiang; Hao Sun; Li Li; Ting Liu; Lin Zhang; Chun Li
Journal:  RSC Adv       Date:  2022-05-18       Impact factor: 4.036

2.  Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol.

Authors:  Kangling Chen; Kefei Li; Jian Deng; Baoqi Zhang; Jinping Lin; Dongzhi Wei
Journal:  Microb Cell Fact       Date:  2016-11-11       Impact factor: 5.328
  2 in total

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