OBJECTIVE: Owing to rising incidence rates in inflammatory bowel disease (IBD), there has been increased interest in causal relationships in pediatric disease. The present population-based inception cohort was recruited in the Oslo area from 2005 to 2007, with the aim of conducting a detailed characterization of treatment-naive patients at diagnosis. MATERIAL AND METHODS: After an invitation was extended to all general practitioners in the catchment area, patients aged <18 years with suspected IBD were diagnosed by proximal and distal endoscopy, MRI, demographic, clinical, and histological and molecular characteristics. Symptomatic non-IBD patients served as controls. RESULTS: Of 100 pediatric patients, 62 had IBD (39 Crohn's disease (CD), 19 ulcerative colitis (UC), 4 IBD unclassified (IBDU)) and 38 other diseases. Median age at diagnosis for IBD was 13.1 years (56.4% males), median symptom duration 6 months, and 69% L3 (Vienna classification). With 195,000 children aged <18 years in the catchment area, the incidence rate of IBD per 100,000/years inhabitants was 10.9 (6.8 for CD, 3.6 for UC, and 0.6 IBDU) and for those aged <16 years (178,500) the incidence rate was 10.6. The higher NOD2 allele frequency among children may partly contribute to the increase. CONCLUSIONS: The results indicate a marked rise in the incidence of CD in contrast to no increase in UC in South-Eastern Norway, compared with the figures from the last 15 years. Time from onset of symptoms to diagnosis still represents a challenge for early characterization in IBD.
OBJECTIVE: Owing to rising incidence rates in inflammatory bowel disease (IBD), there has been increased interest in causal relationships in pediatric disease. The present population-based inception cohort was recruited in the Oslo area from 2005 to 2007, with the aim of conducting a detailed characterization of treatment-naive patients at diagnosis. MATERIAL AND METHODS: After an invitation was extended to all general practitioners in the catchment area, patients aged <18 years with suspected IBD were diagnosed by proximal and distal endoscopy, MRI, demographic, clinical, and histological and molecular characteristics. Symptomatic non-IBD patients served as controls. RESULTS: Of 100 pediatric patients, 62 had IBD (39 Crohn's disease (CD), 19 ulcerative colitis (UC), 4 IBD unclassified (IBDU)) and 38 other diseases. Median age at diagnosis for IBD was 13.1 years (56.4% males), median symptom duration 6 months, and 69% L3 (Vienna classification). With 195,000 children aged <18 years in the catchment area, the incidence rate of IBD per 100,000/years inhabitants was 10.9 (6.8 for CD, 3.6 for UC, and 0.6 IBDU) and for those aged <16 years (178,500) the incidence rate was 10.6. The higher NOD2 allele frequency among children may partly contribute to the increase. CONCLUSIONS: The results indicate a marked rise in the incidence of CD in contrast to no increase in UC in South-Eastern Norway, compared with the figures from the last 15 years. Time from onset of symptoms to diagnosis still represents a challenge for early characterization in IBD.
Authors: J Dhaliwal; T D Walters; D R Mack; H Q Huynh; K Jacobson; A R Otley; J Debruyn; W El-Matary; C Deslandres; M E Sherlock; J N Critch; K Bax; E Seidman; P Jantchou; A Ricciuto; M Rashid; A M Muise; E Wine; M Carroll; S Lawrence; J Van Limbergen; E I Benchimol; P Church; A M Griffiths Journal: J Crohns Colitis Date: 2020-05-21 Impact factor: 9.071
Authors: Xu Yan; Yan Huang; Hui Wang; Min Du; Bret W Hess; Stephen P Ford; Peter W Nathanielsz; Mei-Jun Zhu Journal: Inflamm Bowel Dis Date: 2010-11-28 Impact factor: 5.325
Authors: Silvia Ghione; Hélène Sarter; Mathurin Fumery; Laura Armengol-Debeir; Guillaume Savoye; Delphine Ley; Claire Spyckerelle; Benjamin Pariente; Laurent Peyrin-Biroulet; Dominique Turck; Corinne Gower-Rousseau; J M Andre; M Antonietti; A Aouakli; A Armand; I Aroichane; F Assi; J P Aubet; E Auxenfants; F Ayafi-Ramelot; D Bankovski; B Barbry; N Bardoux; P Baron; A Baudet; B Bazin; A Bebahani; J P Becqwort; V Benet; H Benali; C Benguigui; Ben E Soussan; A Bental; I Berkelmans; J Bernet; K Bernou; C Bernou-Dron; P Bertot; N Bertiaux-Vandaële; V Bertrand; E Billoud; N Biron; B Bismuth; M Bleuet; F Blondel; V Blondin; P Bohon; E Boniface; P Bonnière; E Bonvarlet; P Bonvarlet; A Boruchowicz; R Bostvironnois; M Boualit; B Bouche; C Boudaillez; C Bourgeaux; M Bourgeois; A Bourguet; A Bourienne; J Branche; G Bray; F Brazier; P Breban; H Brihier; V Brung-Lefebvre; P Bulois; P Burgiere; J Butel; J Y Canva; V Canva-Delcambre; J P Capron; F Cardot; P Carpentier; E Cartier; J F Cassar; M Cassagnou; J F Castex; P Catala; S Cattan; S Catteau; B Caujolle; G Cayron; C Chandelier; M Chantre; J Charles; T Charneau; M Chavance-Thelu; D Chirita; A Choteau; J F Claerbout; P Y Clergue; H Coevoet; G Cohen; R Collet; J F Colombel; S Coopman; J Corvisart; A Cortot; F Couttenier; J F Crinquette; V Crombe; I Dadamessi; V Dapvril; T Davion; S Dautreme; J Debas; N Degrave; F Dehont; C Delatre; R Delcenserie; O Delette; T Delgrange; L Delhoustal; J S Delmotte; S Demmane; G Deregnaucourt; P Descombes; J P Desechalliers; P Desmet; P Desreumaux; G Desseaux; P Desurmont; A Devienne; E Devouge; M Devred; A Devroux; A Dewailly; S Dharancy; A Di Fiore; D Djeddi; R Djedir; M L Dreher-Duwat; R Dubois; C Dubuque; P Ducatillon; J Duclay; B Ducrocq; F Ducrot; P Ducrotte; A Dufilho; C Duhamel; D Dujardin; C Dumant-Forest; J L Dupas; F Dupont; Y Duranton; A Duriez; K El Achkar; M El Farisi; C Elie; M C Elie-Legrand; A Elkhaki; M Eoche; D Evrard; J P Evrard; A Fatome; B Filoche; L Finet; M Flahaut; C Flamme; D Foissey; P Fournier; M C Foutrein-Comes; P Foutrein; D Fremond; T Frere; M Fumery; P Gallet; C Gamblin; P S Ganga-Zandzou; R Gérard; G Geslin; Y Gheyssens; N Ghossini; S Ghrib; T Gilbert; B Gillet; D Godard; P Godard; J M Godchaux; R Godchaux; G Goegebeur; O Goria; F Gottrand; P Gower; B Grandmaison; M Groux; C Guedon; J F Guillard; L Guillem; F Guillemot; D Guimber; B Haddouche; S Hakim; D Hanon; V Hautefeuille; P Heckestweiller; G Hecquet; J P Hedde; H Hellal; P E Henneresse; B Heyman; M Heraud; S Herve; P Hochain; L Houssin-Bailly; P Houcke; B Huguenin; S Iobagiu; A Ivanovic; I Iwanicki-Caron; E Janicki; M Jarry; J Jeu; J P Joly; C Jonas; F Katherin; A Kerleveo; A Khachfe; A Kiriakos; J Kiriakos; O Klein; M Kohut; R Kornhauser; D Koutsomanis; J E Laberenne; G Laffineur; M Lagarde; P Lannoy; J Lapchin; M Lapprand; D Laude; R Leblanc; P Lecieux; N Leclerc; C Le Couteulx; J Ledent; J Lefebvre; P Lefiliatre; C Legrand; A Le Grix; P Lelong; B Leluyer; C Lenaerts; L Lepileur; A Leplat; E Lepoutre-Dujardin; H Leroi; M Y Leroy; J P Lesage; X Lesage; J Lesage; I Lescanne-Darchis; J Lescut; D Lescut; B Leurent; P Levy; M Lhermie; A Lion; B Lisambert; F Loire; S Louf; A Louvet; M Luciani; D Lucidarme; J Lugand; O Macaigne; D Maetz; D Maillard; H Mancheron; O Manolache; A B Marks-Brunel; R Marti; F Martin; G Martin; E Marzloff; P Mathurin; J Mauillon; V Maunoury; J L Maupas; B Mesnard; P Metayer; L Methari; B Meurisse; F Meurisse; L Michaud; X Mirmaran; P Modaine; A Monthe; L Morel; P E Mortier; E Moulin; O Mouterde; J Mudry; M Nachury; NʼGuyen E Khac; B Notteghem; V Ollevier; A Ostyn; A Ouraghi; D Ouvry; B Paillot; N Panien-Claudot; C Paoletti; A Papazian; B Parent; B Pariente; J C Paris; P Patrier; L Paupart; B Pauwels; M Pauwels; R Petit; M Piat; S Piotte; C Plane; B Plouvier; E Pollet; P Pommelet; D Pop; C Pordes; G Pouchain; P Prades; A Prevost; J C Prevost; B Quesnel; A M Queuniet; J F Quinton; A Rabache; P Rabelle; G Raclot; S Ratajczyk; D Rault; V Razemon; N Reix; M Revillon; C Richez; P Robinson; J Rodriguez; J Roger; J M Roux; A Rudelli; A Saber; G Savoye; P Schlosseberg; M Segrestin; D Seguy; M Serin; A Seryer; F Sevenet; N Shekh; J Silvie; V Simon; C Spyckerelle; N Talbodec; A Techy; J L Thelu; A Thevenin; H Thiebault; J Thomas; J M Thorel; G Tielman; M Tode; J Toisin; J Tonnel; J Y Touchais; Y Touze; J L Tranvouez; C Triplet; D Turck; S Uhlen; E Vaillant; C Valmage; D Vanco; H Vandamme; E Vanderbecq; Vander E Eecken; P Vandermolen; P Vandevenne; L Vandeville; A Vandewalle; C Vandewalle; P Vaneslander; J P Vanhoove; A Vanrenterghem; P Varlet; I Vasies; G Verbiese; G Vernier-Massouille; P Vermelle; C Verne; P Vezilier-Cocq; B Vigneron; M Vincendet; J Viot; Y M Voiment; A Wacrenier; L Waeghemaecker; J Y Wallez; M Wantiez; F Wartel; J Weber; J L Willocquet; N Wizla; E Wolschies; A Zalar; B Zaouri; A Zellweger; C Ziade Journal: Am J Gastroenterol Date: 2017-08-15 Impact factor: 10.864
Authors: Ioannis D Kostakis; Kyriaki G Cholidou; Aristeidis G Vaiopoulos; Ioannis S Vlachos; Despina Perrea; George Vaos Journal: Dig Dis Sci Date: 2012-08-17 Impact factor: 3.199