Literature DB >> 19116544

Corneal neurotization: a novel solution to neurotrophic keratopathy.

Julia K Terzis1, Marylou M Dryer, Bruce I Bodner.   

Abstract

BACKGROUND: This study was designed to evaluate the efficacy of direct corneal neurotization using contralateral supraorbital and supratrochlear nerves in patients with unilateral facial palsy and corneal anesthesia. A novel surgical procedure in which these donor nerve branches are inserted at the contralateral anesthetic corneal limbus for sensory neurotization is described.
METHODS: The charts of six patients were reviewed thoroughly to evaluate changes in corneal sensibility following surgery for direct corneal neurotization. Visual acuity, blink reflex, donor deficit, synesthesia, long-term corneal health, and several psychosocial measures and overall patient satisfaction with the procedure are reported.
RESULTS: Six patients with an average denervation time of 7.00 +/- 8.56 years before surgery were followed for an average period of 16.3 +/- 2.42 years. All six eyes showed improvement of corneal sensibility, visual acuity, and corneal health and remained free of ulcers or other signs of advancing neurotropic keratopathy. Average corneal sensibility improved from 2.00 +/- 4.47 mm before surgery to 278.00 +/- 226.00 mm following corneal neurotization (p < 0.016).
CONCLUSIONS: Direct neurotization of the cornea using the contralateral supraorbital and supratrochlear branches of the ophthalmic division of the trigeminal nerve appears to be an effective method of restoring the corneal sensibility in patients with unilateral facial palsy and anesthetic cornea. This technique preserves ocular anatomy and cosmesis and restores function by improving corneal health and visual acuity.

Entities:  

Mesh:

Year:  2009        PMID: 19116544     DOI: 10.1097/PRS.0b013e3181904d3a

Source DB:  PubMed          Journal:  Plast Reconstr Surg        ISSN: 0032-1052            Impact factor:   4.730


  26 in total

1.  Anatomic characteristics of supraorbital and supratrochlear nerves relevant to their use in corneal neurotization.

Authors:  Leahthan F Domeshek; Daniel A Hunter; Katherine Santosa; Steven M Couch; Asim Ali; Gregory H Borschel; Ronald M Zuker; Alison K Snyder-Warwick
Journal:  Eye (Lond)       Date:  2018-09-27       Impact factor: 3.775

Review 2.  Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes.

Authors:  Catherine Y Liu; Andrea C Arteaga; Sammie E Fung; M Soledad Cortina; Ilya M Leyngold; Vinay K Aakalu
Journal:  Ocul Surf       Date:  2021-02-26       Impact factor: 5.033

3.  14th EUNOS Congress: PORTO, PORTUGAL, 16-19 JUNE 2019.

Authors: 
Journal:  Neuroophthalmology       Date:  2019-06-07

4.  Eyelid reanimation, neurotisation, and transplantation of the cornea in a patient with facial palsy.

Authors:  Fabiana Allevi; Paolo Fogagnolo; Luca Rossetti; Federico Biglioli
Journal:  BMJ Case Rep       Date:  2014-08-19

Review 5.  Regenerative therapy for the Cornea.

Authors:  Ajay Kumar; Hongmin Yun; Martha L Funderburgh; Yiqin Du
Journal:  Prog Retin Eye Res       Date:  2021-09-14       Impact factor: 21.198

Review 6.  [Current and experimental treatment approaches for neurotrophic keratopathy].

Authors:  J Alder; S Mertsch; J Menzel-Severing; G Geerling
Journal:  Ophthalmologe       Date:  2019-02       Impact factor: 1.059

7.  In Vivo Corneal Confocal Microscopy: Pre- and Post-operative Evaluation in a Case of Corneal Neurotization.

Authors:  Roberto Ebner; Guillermo Fridrich; Mariano Socolovsky; Analía Luna; Juan Oscar Croxatto
Journal:  Neuroophthalmology       Date:  2019-01-25

Review 8.  [Corneal neurotization].

Authors:  J N Lueke; C Holtmann; K Beseoglu; G Geerling
Journal:  Ophthalmologe       Date:  2020-03       Impact factor: 1.059

Review 9.  Alternative therapies for dry eye disease.

Authors:  Rhiya Mittal; Sneh Patel; Anat Galor
Journal:  Curr Opin Ophthalmol       Date:  2021-07-01       Impact factor: 4.299

10.  Functional and Structural Changes Following Corneal Neurotisation in the Management of Neurotrophic Keratopathy: UK Single Centre Series.

Authors:  Mohamed Elalfy; Sundas Maqsood; Scott Hau; Ruben Y Kannan; Charles Nduka; Samer Hamada; Raman Malhotra
Journal:  Clin Ophthalmol       Date:  2021-05-24
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