BACKGROUND: Evidence indicates that vitamin E has anticarcinogenic properties for gastrointestinal cancers; however, few studies have examined this with respect to exocrine pancreatic cancer. OBJECTIVE: The objective was to examine whether vitamin E intake and serum alpha-tocopherol concentrations were prospectively associated with exocrine pancreatic cancer. DESIGN: We conducted a cohort analysis of prediagnostic vitamin E intake (4 tocopherols, 4 tocotrienols), serum alpha-tocopherol concentrations, and pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male Finnish smokers aged 50-69 y at baseline. During follow-up from 1985 to 2004 (maximum: 19.4 y; median: 16 y), 318 incident cases were diagnosed among cohort participants with complete serum samples (n = 29,092); 306 cases had complete dietary data (n = 27,111). Cox proportional hazards models adjusted for age, smoking history, history of diabetes mellitus, and/or serum cholesterol were used to calculate hazard ratios (HRs) and 95% CIs. RESULTS: Higher alpha-tocopherol concentrations were associated with lower pancreatic cancer risk (highest compared with lowest quintile, HR: 0.52; 95% CI: 0.34, 0.80; P for trend = 0.03; continuous HR: 0.91; 95% CI: 0.84, 0.99). Polyunsaturated fat, a putative prooxidant nutrient, modified the association such that the inverse alpha-tocopherol association was most pronounced in subjects with a high polyunsaturated fat intake (ie, >9.9 g/d; highest compared with lowest quintile, HR: 0.38; 95% CI: 0.20, 0.70; P for trend = 0.03; continuous HR: 0.86; 95% CI: 0.75, 0.97; P for interaction = 0.05 and 0.02, respectively). No associations were observed for dietary tocopherols and tocotrienols. CONCLUSION: Our results support the hypothesis that higher alpha-tocopherol concentrations may play a protective role in pancreatic carcinogenesis in male smokers.
BACKGROUND: Evidence indicates that vitamin E has anticarcinogenic properties for gastrointestinal cancers; however, few studies have examined this with respect to exocrine pancreatic cancer. OBJECTIVE: The objective was to examine whether vitamin E intake and serum alpha-tocopherol concentrations were prospectively associated with exocrine pancreatic cancer. DESIGN: We conducted a cohort analysis of prediagnostic vitamin E intake (4 tocopherols, 4 tocotrienols), serum alpha-tocopherol concentrations, and pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male Finnish smokers aged 50-69 y at baseline. During follow-up from 1985 to 2004 (maximum: 19.4 y; median: 16 y), 318 incident cases were diagnosed among cohort participants with complete serum samples (n = 29,092); 306 cases had complete dietary data (n = 27,111). Cox proportional hazards models adjusted for age, smoking history, history of diabetes mellitus, and/or serum cholesterol were used to calculate hazard ratios (HRs) and 95% CIs. RESULTS: Higher alpha-tocopherol concentrations were associated with lower pancreatic cancer risk (highest compared with lowest quintile, HR: 0.52; 95% CI: 0.34, 0.80; P for trend = 0.03; continuous HR: 0.91; 95% CI: 0.84, 0.99). Polyunsaturated fat, a putative prooxidant nutrient, modified the association such that the inverse alpha-tocopherol association was most pronounced in subjects with a high polyunsaturated fat intake (ie, >9.9 g/d; highest compared with lowest quintile, HR: 0.38; 95% CI: 0.20, 0.70; P for trend = 0.03; continuous HR: 0.86; 95% CI: 0.75, 0.97; P for interaction = 0.05 and 0.02, respectively). No associations were observed for dietary tocopherols and tocotrienols. CONCLUSION: Our results support the hypothesis that higher alpha-tocopherol concentrations may play a protective role in pancreatic carcinogenesis in male smokers.
Authors: P Pietinen; A M Hartman; E Haapa; L Räsänen; J Haapakoski; J Palmgren; D Albanes; J Virtamo; J K Huttunen Journal: Am J Epidemiol Date: 1988-09 Impact factor: 4.897
Authors: P Knekt; A Aromaa; J Maatela; R K Aaran; T Nikkari; M Hakama; T Hakulinen; R Peto; E Saxén; L Teppo Journal: Am J Epidemiol Date: 1988-01 Impact factor: 4.897
Authors: Jianjun Zhang; Xuemei Zhang; Ishwori B Dhakal; Myron D Gross; Fred F Kadlubar; Kristin E Anderson Journal: Int J Mol Epidemiol Genet Date: 2011-06-05
Authors: Rick J Jansen; Dennis P Robinson; Rachael Z Stolzenberg-Solomon; William R Bamlet; Mariza de Andrade; Ann L Oberg; Kari G Rabe; Kristin E Anderson; Janet E Olson; Rashmi Sinha; Gloria M Petersen Journal: J Gastrointest Cancer Date: 2013-06
Authors: Eva M Navarrete-Muñoz; Petra A Wark; Dora Romaguera; Nirmala Bhoo-Pathy; Dominique Michaud; Esther Molina-Montes; Anne Tjønneland; Anja Olsen; Kim Overvad; Marie-Christine Boutron-Ruault; Françoise Clavel-Chapelon; Guy Fagherazzi; Verena A Katzke; Tilman Kühn; Annika Steffen; Antonia Trichopoulou; Eleni Klinaki; Eleni-Maria Papatesta; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Alessio Naccarati; Amalia Mattiello; Petra H Peeters; Charlotta Rylander; Christine L Parr; Guri Skeie; Elisabete Weiderpass; J Ramón Quirós; Eric J Duell; Miren Dorronsoro; José María Huerta; Eva Ardanaz; Nick Wareham; Kay-Tee Khaw; Ruth C Travis; Tim Key; Magdalena Stepien; Heinz Freisling; Elio Riboli; H Bas Bueno-de-Mesquita Journal: Am J Clin Nutr Date: 2016-08-10 Impact factor: 7.045