| Literature DB >> 19115980 |
Pengfei Li1, Shigang Wen, Feng Yu, Qiaoxia Liu, Wenjun Li, Yongcan Wang, Xinmiao Liang, Jinxing Ye.
Abstract
A novel type of primary amine thiourea organocatalysts derived from 1,2-diaminocyclohexane and 9-amino (9-deoxy) cinchona alkaloid was developed into asymmetric Michael addition of malonates to enones. A series of cyclic and acyclic enones could react very well with different malonates in the presence of 4 with 0.5-10 mol % catalyst loading affording chiral Michael adducts with excellent yields and ee values.Entities:
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Year: 2009 PMID： 19115980 DOI： 10.1021/ol802892h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005