| Literature DB >> 19115095 |
Ming-Chin Lu1, Yen-Ting Huang, Jia-Horng Lin, Chun-Hsu Yao, Ching-Wen Lou, Chin-Chuan Tsai, Yueh-Sheng Chen.
Abstract
We evaluated peripheral nerve regeneration using a biodegradable multi-layer microbraided polylactic acid (PLA) fiber-reinforced conduit. Biodegradability of the PLA conduit and its effectiveness as a guidance channel were examined as it was used to repair a 10 mm gap in the rat sciatic nerve. As a result, tube fragmentation was not obvious and successful regeneration through the gap occurred in all the conduits at 8 weeks after operation. These results indicate the superiority of the PLA materials and suggest that the multi-layer microbraided PLA fiber-reinforced conduits provide a promising tool for neuro-regeneration.Entities:
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Year: 2008 PMID： 19115095 DOI： 10.1007/s10856-008-3646-4
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896