Literature DB >> 19114990

Non-Smad pathways in TGF-beta signaling.

Ying E Zhang1.   

Abstract

Transforming growth factor-beta utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream cellular responses. These non-Smad pathways include various branches of MAP kinase pathways, Rho-like GTPase signaling pathways, and phosphatidylinositol-3-kinase/AKT pathways. This review focuses on recent advances in the understanding of the molecular and biochemical mechanisms of non-Smad pathways. In addition, functions of these non-Smad pathways are also discussed.

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Year:  2009        PMID： 19114990      PMCID： PMC2635127          DOI： 10.1038/cr.2008.328

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  93 in total

1.  Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription.

Authors:  M E Engel; M A McDonnell; B K Law; H L Moses
Journal:  J Biol Chem       Date:  1999-12-24       Impact factor: 5.157

Review 2.  TGFbeta signaling in growth control, cancer, and heritable disorders.

Authors:  J Massagué; S W Blain; R S Lo
Journal:  Cell       Date:  2000-10-13       Impact factor: 41.582

Review 3.  Cell signaling by receptor tyrosine kinases.

Authors:  J Schlessinger
Journal:  Cell       Date:  2000-10-13       Impact factor: 41.582

4.  BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6.

Authors:  N Kimura; R Matsuo; H Shibuya; K Nakashima; T Taga
Journal:  J Biol Chem       Date:  2000-06-09       Impact factor: 5.157

5.  Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

Authors:  A V Bakin; A K Tomlinson; N A Bhowmick; H L Moses; C L Arteaga
Journal:  J Biol Chem       Date:  2000-11-24       Impact factor: 5.157

6.  TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.

Authors:  C Petritsch; H Beug; A Balmain; M Oft
Journal:  Genes Dev       Date:  2000-12-15       Impact factor: 11.361

Review 7.  Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.

Authors:  V Janssens; J Goris
Journal:  Biochem J       Date:  2001-02-01       Impact factor: 3.857

Review 8.  TGFbeta in Cancer.

Authors:  Joan Massagué
Journal:  Cell       Date:  2008-07-25       Impact factor: 41.582

9.  Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.

Authors:  Jason J Northey; Juliann Chmielecki; Elaine Ngan; Caterina Russo; Matthew G Annis; William J Muller; Peter M Siegel
Journal:  Mol Cell Biol       Date:  2008-03-10       Impact factor: 4.272

10.  The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.

Authors:  Alessandro Sorrentino; Noopur Thakur; Susanne Grimsby; Anders Marcusson; Verena von Bulow; Norbert Schuster; Shouting Zhang; Carl-Henrik Heldin; Maréne Landström
Journal:  Nat Cell Biol       Date:  2008-08-31       Impact factor: 28.824
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  717 in total

1.  Genetic variations in the transforming growth factor-beta pathway as predictors of survival in advanced non-small cell lung cancer.

Authors:  Moubin Lin; David J Stewart; Margaret R Spitz; Michelle A T Hildebrandt; Charles Lu; Jie Lin; Jian Gu; Maosheng Huang; Scott M Lippman; Xifeng Wu
Journal:  Carcinogenesis       Date:  2011-04-22       Impact factor: 4.944

2.  Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway.

Authors:  Qiaodan Zhou; Rui Zeng; Chuou Xu; Lili Liu; Lin Chen; Pei Kou; Guangchang Pei; Shoujun Bai; Yamin Zhang; Caixia Li; Song Rong; Min Han; Gang Xu
Journal:  J Mol Med (Berl)       Date:  2011-11-25       Impact factor: 4.599

3.  The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.

Authors:  Qunyan Jin; Wei Ding; Kathleen M Mulder
Journal:  J Biol Chem       Date:  2012-05-27       Impact factor: 5.157

Review 4.  The microRNA networks of TGFβ signaling in cancer.

Authors:  V P Sivadas; S Kannan
Journal:  Tumour Biol       Date:  2013-12-10

5.  The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.

Authors:  Alex Kiepas; Elena Voorand; Julien Senecal; Ryuhjin Ahn; Matthew G Annis; Kévin Jacquet; George Tali; Nicolas Bisson; Josie Ursini-Siegel; Peter M Siegel; Claire M Brown
Journal:  J Biol Chem       Date:  2020-04-16       Impact factor: 5.157

Review 6.  TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1.

Authors:  Breege V Howley; Philip H Howe
Journal:  Cytokine       Date:  2018-02-01       Impact factor: 3.861

7.  IPF pathogenesis is dependent upon TGFβ induction of IGF-1.

Authors:  Danielle M Hernandez; Jeong-Han Kang; Malay Choudhury; Mahefatiana Andrianifahanana; Xueqian Yin; Andrew H Limper; Edward B Leof
Journal:  FASEB J       Date:  2020-02-17       Impact factor: 5.191

8.  TGF-β regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes.

Authors:  Sangeeta Kowli; Rupa Velidandla; Kim E Creek; Lucia Pirisi
Journal:  Virology       Date:  2013-09-19       Impact factor: 3.616

9.  Transforming growth factor-β1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants.

Authors:  Bapi Pahar; Diganta Pan; Wendy Lala; Carys S Kenway-Lynch; Arpita Das
Journal:  Clin Immunol       Date:  2015-03-10       Impact factor: 3.969

10.  Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.

Authors:  Afsaneh Majdazari; Jutta Stubbusch; Christian M Müller; Melanie Hennchen; Marlen Weber; Chu-Xia Deng; Yuji Mishina; Günther Schütz; Thomas Deller; Hermann Rohrer
Journal:  J Neurosci       Date:  2013-09-18       Impact factor: 6.167
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