| Literature DB >> 19114121 |
Chih-Hsiang Leng1, Shih-Jen Liu, Jy-Ping Tsai, Yi-Shiuan Li, Mei-Yu Chen, Hsueh-Hung Liu, Shu-Pei Lien, Andrew Yueh, Kuang-Nan Hsiao, Li-Wei Lai, Feng-Chuan Liu, Pele Chong, Hsin-Wei Chen.
Abstract
A novel dengue vaccine candidate comprised of a consensus dengue virus envelope protein domain III (cED III) was developed to fight against dengue virus infection. The amino acid sequence of this novel cED III was obtained by alignment of amino acid sequences from different isolates of the four serotypes of dengue viruses. A proof-of-concept study demonstrated that BALB/c mice immunized with the recombinant cED III developed neutralizing antibodies against all serotypes of dengue virus. Moreover, formulation of recombinant cED III with aluminum phosphate could induce long-lasting antibody responses and anamnestic neutralizing antibody responses following challenge with dengue virus at week 28 after priming. These results demonstrate the possibility of developing a single tetravalent vaccine against dengue viral infections.Entities:
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Year: 2008 PMID： 19114121 DOI： 10.1016/j.micinf.2008.12.004
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700