Literature DB >> 1911315

Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells.

M Akiyama1, T Hashimoto, M Sugiura, T Nishikawa.   

Abstract

The ultrastructural localization of the pemphigus vulgaris (PV) and pemphigus foliaceus (PF) antigens in cultured human squamous carcinoma cells was observed using immunogold electron microscopy. Both the PV and PF autoantibodies bound only to the extracellular portion of the desmosomal structures. After incubation at 37 degrees C, the PV antigen-antibody complexes were observed within the cultured cells. PV and PF antigen expression was markedly reduced when the cells were cultured in medium with a low Ca2+ concentration.

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Year:  1991        PMID： 1911315     DOI： 10.1111/j.1365-2133.1991.tb14746.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  6 in total

1.  No significant change of glycoconjugates exists in the epidermis of familial benign chronic pemphigus.

Authors:  M Akiyama; M Sugiura; H Shimizu; T Nishikawa
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

2.  Ultrastructural localization of autoantigens of intercellular IgA vesiculopustular dermatosis in cultured human squamous cell carcinoma cells.

Authors:  M Akiyama; T Hashimoto; M Sugiura; T Nishikawa
Journal:  Arch Dermatol Res       Date:  1992       Impact factor: 3.017

3.  Binding of autoantibodies is not restricted to desmosomes in pemphigus vulgaris: comparison of 14 cases of pemphigus vulgaris and 10 cases of pemphigus foliaceus studied by western immunoblot and immunoelectron microscopy.

Authors:  C Bédane; C Prost; E Thomine; L Intrator; P Joly; F Caux; M Blecker; P Bernard; M J Leboutet; F Tron; P Lauret; J M Bonnetblanc; L Dubertret
Journal:  Arch Dermatol Res       Date:  1996-06       Impact factor: 3.017

4.  Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.

Authors:  P J Koch; M G Mahoney; H Ishikawa; L Pulkkinen; J Uitto; L Shultz; G F Murphy; D Whitaker-Menezes; J R Stanley
Journal:  J Cell Biol       Date:  1997-06-02       Impact factor: 10.539

5.  Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes.

Authors:  S Kárpáti; M Amagai; R Prussick; K Cehrs; J R Stanley
Journal:  J Cell Biol       Date:  1993-07       Impact factor: 10.539

Review 6.  Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated Model.

Authors:  Thomas Sajda; Animesh A Sinha
Journal:  Front Immunol       Date:  2018-04-19       Impact factor: 7.561
  6 in total

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