Literature DB >> 19112795

HBOC-201: the multi-purpose oxygen therapeutic.

Gregory P Dubé1, Pascal Vranckx, A Gerson Greenburg.   

Abstract

Clinical and preclinical studies have revealed a diverse array of indications in which the effectiveness of HBOC-201 has been demonstrated or appears likely. Included among these are indications involving cardiac and peripheral ischaemia in which this oxygen therapeutic may prove to be an important tool in the armamentarium of the cardiologist and surgeon. Preclinical studies and clinical trials are under way to further delineate and optimise the role of HBOC-201 as an oxygen therapeutic in cardiovascular medicine.

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Year:  2008        PMID： 19112795     DOI： 10.4244/eijv4i1a26

Source DB:  PubMed          Journal:  EuroIntervention        ISSN： 1774-024X            Impact factor:   6.534


  7 in total

1.  Effects of a hemoglobin-based oxygen carrier (HBOC-201) and derivatives with altered oxygen affinity and viscosity on systemic and microcirculatory variables in a top-load rat model.

Authors:  Bjorn Kyungsuck Song; William H Nugent; Paula F Moon-Massat; Roland N Pittman
Journal:  Microvasc Res       Date:  2014-07-18       Impact factor: 3.514

2.  Differential sensitivities of pulmonary and coronary arteries to hemoglobin-based oxygen carriers and nitrovasodilators: study in a bovine ex vivo model of vascular strips.

Authors:  Vera Fonseca; Jessica Avizinis; Paula Moon-Massat; Daniel Freilich; Hae Won Kim; Chi-Ming Hai
Journal:  Vascul Pharmacol       Date:  2009-12-22       Impact factor: 5.773

3.  Hemoglobin infusion does not alter murine pulmonary vascular tone.

Authors:  Arkadi Beloiartsev; David M Baron; Binglan Yu; Kenneth D Bloch; Warren M Zapol
Journal:  Nitric Oxide       Date:  2013-01-08       Impact factor: 4.427

4.  Normothermic machine perfusion of donor livers without the need for human blood products.

Authors:  Alix P M Matton; Laura C Burlage; Rianne van Rijn; Yvonne de Vries; Shanice A Karangwa; Maarten W Nijsten; Annette S H Gouw; Janneke Wiersema-Buist; Jelle Adelmeijer; Andrie C Westerkamp; Ton Lisman; Robert J Porte
Journal:  Liver Transpl       Date:  2018-04       Impact factor: 5.799

5.  Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness.

Authors:  Maria M Rubinstein; Cheryl Goss; Scott T Avecilla; Gregory P Dubé; Gregory J Riely; Jodi V Mones
Journal:  Clin Case Rep       Date:  2019-12-26

Review 6.  Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation.

Authors:  Min Cao; Guoqing Wang; Hongli He; Ruiming Yue; Yong Zhao; Lingai Pan; Weiwei Huang; Yang Guo; Tao Yin; Lina Ma; Dingding Zhang; Xiaobo Huang
Journal:  Front Pharmacol       Date:  2021-11-30       Impact factor: 5.810

Review 7.  Investigation on artificial blood or substitute blood replace the natural blood.

Authors:  Sh Keyhanian; M Ebrahimifard; M Zandi
Journal:  Iran J Ped Hematol Oncol       Date:  2014-04-20
  7 in total

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