Literature DB >> 19112691

Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4.

Eduardo Pauls1, Ester Ballana, Gemma Moncunill, Margarida Bofill, Bonaventura Clotet, Cristina Ramo-Tello, José A Esté.   

Abstract

The alpha4beta7 integrin has been shown to serve as a coreceptor for HIV. One anti-alpha4 integrin agent (natalizumab) has been approved for the treatment of multiple sclerosis and Crohn's disease. We found that activation of CD4+ T cells with retinoic acid induced the upregulation of alpha4 and beta7 integrins. However, natalizumab failed to block the replication of HIV-1 strains in lymphoid MT-4 cells or CD4+ T cells at concentrations up to 125microg/ml. Our results suggest that alpha4 integrins are not essential cofactors for HIV replication.

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Year:  2009        PMID： 19112691     DOI： 10.1097/qad.0b013e328320a7f8

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  9 in total

Review 1.  Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there.

Authors:  Christopher C Denucci; Jason S Mitchell; Yoji Shimizu
Journal:  Crit Rev Immunol       Date:  2009       Impact factor: 2.214

2.  Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

Authors:  David Plotnik; Wenjin Guo; Brad Cleveland; Priska von Haller; Jimmy K Eng; Miklos Guttman; Kelly K Lee; James Arthos; Shiu-Lok Hu
Journal:  J Virol       Date:  2017-10-13       Impact factor: 5.103

3.  Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of α4β7 integrin.

Authors:  Behzad Etemad; Oscar A Gonzalez; Sean McDonough; Victor Pena-Cruz; Manish Sagar
Journal:  J Acquir Immune Defic Syndr       Date:  2013-11-01       Impact factor: 3.731

4.  Integrin α4β7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism.

Authors:  Jian Ding; Carley Tasker; Pierre Lespinasse; Jihong Dai; Patricia Fitzgerald-Bocarsly; Wuyuan Lu; Debra Heller; Theresa Li-Yun Chang
Journal:  J Acquir Immune Defic Syndr       Date:  2015-08-15       Impact factor: 3.731

5.  Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.

Authors:  Nicholas F Parrish; Craig B Wilen; Lauren B Banks; Shilpa S Iyer; Jennifer M Pfaff; Jesus F Salazar-Gonzalez; Maria G Salazar; Julie M Decker; Erica H Parrish; Anna Berg; Jennifer Hopper; Bhavna Hora; Amit Kumar; Tatenda Mahlokozera; Sally Yuan; Charl Coleman; Marion Vermeulen; Haitao Ding; Christina Ochsenbauer; John C Tilton; Sallie R Permar; John C Kappes; Michael R Betts; Michael P Busch; Feng Gao; David Montefiori; Barton F Haynes; George M Shaw; Beatrice H Hahn; Robert W Doms
Journal:  PLoS Pathog       Date:  2012-05-31       Impact factor: 6.823

6.  Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor.

Authors:  Kristina K Peachman; Nicos Karasavvas; Agnes-Laurence Chenine; Robert McLinden; Supachai Rerks-Ngarm; Kaewkungwal Jaranit; Sorachai Nitayaphan; Punnee Pitisuttithum; Sodsai Tovanabutra; Susan Zolla-Pazner; Nelson L Michael; Jerome H Kim; Carl R Alving; Mangala Rao
Journal:  PLoS One       Date:  2015-12-01       Impact factor: 3.240

7.  New Diagnosis of Acquired Immunodeficiency Syndrome in a Patient With Crohn's Disease.

Authors:  Maya Aharoni Golan; Roni Weisshof; Yunwei Wang; David T Rubin
Journal:  ACG Case Rep J       Date:  2019-04-08

8.  Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV-infected rhesus macaques.

Authors:  Widade Ziani; Jiasheng Shao; Angela Fang; Patrick J Connolly; Xiaolei Wang; Ronald S Veazey; Huanbin Xu
Journal:  FASEB J       Date:  2021-02       Impact factor: 5.834

9.  Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.

Authors:  Oliver F Brandenberg; Peter Rusert; Carsten Magnus; Jacqueline Weber; Jürg Böni; Huldrych F Günthard; Roland R Regoes; Alexandra Trkola
Journal:  Retrovirology       Date:  2014-09-25       Impact factor: 4.602
  9 in total

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