Literature DB >> 19112020

New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of alpha-lapachone derivatives under microwave irradiation.

Ping Wei1, Xiaohong Zhang, Shujiang Tu, Shu Yan, Hanjie Ying, Pingkai Ouyang.   

Abstract

A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally.

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Year:  2008        PMID： 19112020     DOI： 10.1016/j.bmcl.2008.12.006

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines.

Authors:  Marcília P Costa; Anderson C S Feitosa; Fátima C E Oliveira; Bruno C Cavalcanti; Gleiston G Dias; Ewerton W S Caetano; Francisco A M Sales; Valder N Freire; Stefano Di Fiore; Rainer Fischer; Luiz O Ladeira; Eufrânio N da Silva Júnior; Claudia Pessoa
Journal:  Medchemcomm       Date:  2017-09-07       Impact factor: 3.597

2.  Enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes catalyzed by binaphthyl-derived organocatalysts.

Authors:  Saet Byeol Woo; Dae Young Kim
Journal:  Beilstein J Org Chem       Date:  2012-05-07       Impact factor: 2.883
  2 in total

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