Literature DB >> 19112019

Curcumin is a potent DNA hypomethylation agent.

Zhongfa Liu1, Zhiliang Xie, William Jones, Ryan E Pavlovicz, Shujun Liu, Jianhua Yu, Pui-kai Li, Jiayuh Lin, Jame R Fuchs, Guido Marcucci, Chenglong Li, Kenneth K Chan.   

Abstract

Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19112019     DOI： 10.1016/j.bmcl.2008.12.041

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  87 in total

1.  Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.

Authors:  Limin Shu; Tin Oo Khor; Jong-Hun Lee; Sarandeep S S Boyanapalli; Ying Huang; Tien-Yuan Wu; Constance L-L Saw; Ka-Lung Cheung; Ah-Ng Tony Kong
Journal:  AAPS J       Date:  2011-09-22       Impact factor: 4.009

2.  Epigenetic changes induced by curcumin and other natural compounds.

Authors:  Simone Reuter; Subash C Gupta; Byoungduck Park; Ajay Goel; Bharat B Aggarwal
Journal:  Genes Nutr       Date:  2011-04-24       Impact factor: 5.523

Review 3.  Targeting the epigenome with bioactive food components for cancer prevention.

Authors:  Thomas Prates Ong; Fernando Salvador Moreno; Sharon Ann Ross
Journal:  J Nutrigenet Nutrigenomics       Date:  2012-02-22

4.  Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice.

Authors:  Liu Zhongfa; Ming Chiu; Jiang Wang; Wei Chen; Winston Yen; Patty Fan-Havard; Lisa D Yee; Kenneth K Chan
Journal:  Cancer Chemother Pharmacol       Date:  2011-10-04       Impact factor: 3.333

5.  Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin.

Authors:  Markus Griesser; Valentina Pistis; Takashi Suzuki; Noemi Tejera; Derek A Pratt; Claus Schneider
Journal:  J Biol Chem       Date:  2010-11-11       Impact factor: 5.157

6.  Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer.

Authors:  Sharanjot Saini; Sumit Arora; Shahana Majid; Varahram Shahryari; Yi Chen; Guoren Deng; Soichiro Yamamura; Koji Ueno; Rajvir Dahiya
Journal:  Cancer Prev Res (Phila)       Date:  2011-08-11

Review 7.  Epigenetic mechanisms in anti-cancer actions of bioactive food components--the implications in cancer prevention.

Authors:  B Stefanska; H Karlic; F Varga; K Fabianowska-Majewska; Ag Haslberger
Journal:  Br J Pharmacol       Date:  2012-09       Impact factor: 8.739

8.  DNA Methylation and Flavonoids in Genitourinary Cancers.

Authors:  Neelam Mukherjee; Addanki P Kumar; Rita Ghosh
Journal:  Curr Pharmacol Rep       Date:  2015-04-01

9.  Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.

Authors:  Yue Guo; Limin Shu; Chengyue Zhang; Zheng-Yuan Su; Ah-Ng Tony Kong
Journal:  Biochem Pharmacol       Date:  2015-01-29       Impact factor: 5.858

Review 10.  Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition.

Authors:  Sharmila Shankar; Dhruv Kumar; Rakesh K Srivastava
Journal:  Pharmacol Ther       Date:  2012-11-16       Impact factor: 12.310
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.