| Literature DB >> 19111873 |
Lawrence N Kwong1, Lynda Chin.
Abstract
The enormity and complexity of cancer genome data present significant challenges in downstream validation of novel oncogenes and tumor suppressors. In this issue of Cancer Cell, Hu et al. evaluate candidate oncogenes in a recurrent amplification in poor-prognosis breast cancers. They identify and validate the prometastatic gene metadherin (MTDH) as a key modulator of endothelial adhesion and chemoresistance.Entities:
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Year: 2009 PMID： 19111873 DOI： 10.1016/j.ccr.2008.12.007
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743