Atrial fibrillation: unanswered questions and future directions.

The seminal demonstration of the role of pulmonary vein triggers in the pathogenesis of atrial fibrillation (AF) and the potential therapeutic role of catheter ablation to treat patients who have paroxysmal AF was provided just over a decade ago. This initial observation ushered in the modern era of catheter ablation to treat patients who have AF, and tremendous progress has been made in understanding its pathogenesis and the catheter approaches to treating this rhythm. This article reflects on some of the major unanswered questions about AF management, and the future technologic and investigational directions being explored in the nonpharmacologic management of AF.