| Literature DB >> 19111463 |
Biqi Wu1, Diane H Boschelli, Julie Lee, Xiaoke Yang, Divya Chaudhary.
Abstract
Thieno[2,3-b]pyridine-5-carbonitrile 16 with a 4-methyl-5-indolylamine at C-4 and a 5-methoxy-2-(dimethylamino)-methylphenyl group at C-2 had an IC(50) value of 16 nM for the inhibition of PKCtheta. While moderate inhibition of PKCdelta was also observed (IC(50)=130 nM), 16 had IC(50) values of greater than 5 microM against Lyn and other members of the Src kinase family.Entities:
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Year: 2008 PMID： 19111463 DOI： 10.1016/j.bmcl.2008.12.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823