Literature DB >> 19111387

Caspase-8 in cancer biology and therapy.

Simone Fulda1.   

Abstract

Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human diseases. For example, caspase-8 is inactivated in a variety of human cancers, which may promote tumor progression as well as resistance to current treatment approaches. Therefore, caspase-8 presents a promising target to restore defective apoptosis programs in cancers in order to overcome resistance.

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Year:  2008        PMID： 19111387     DOI： 10.1016/j.canlet.2008.11.023

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  61 in total

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Journal:  J Biol Inorg Chem       Date:  2015-05-24       Impact factor: 3.358

2.  Cellular stress responses: cell survival and cell death.

Authors:  Simone Fulda; Adrienne M Gorman; Osamu Hori; Afshin Samali
Journal:  Int J Cell Biol       Date:  2010-02-21

3.  Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells.

Authors:  Qingdi Quentin Li; Rebecca X Lee; Huasheng Liang; Yuhua Zhong; Eddie Reed
Journal:  Med Oncol       Date:  2013-01-01       Impact factor: 3.064

4.  Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos.

Authors:  Qiang Zhang; Jinping Cheng; Qi Xin
Journal:  Ecotoxicology       Date:  2015-01-15       Impact factor: 2.823

Review 5.  Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation.

Authors:  A D Garg; E Romano; N Rufo; P Agostinis
Journal:  Cell Death Differ       Date:  2016-02-19       Impact factor: 15.828

Review 6.  Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand.

Authors:  Nor Saadah M Azahri; Mary M Kavurma
Journal:  Cell Mol Life Sci       Date:  2013-01-18       Impact factor: 9.261

7.  Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Authors:  Changyou Li; Ann Marie Egloff; Malabika Sen; Jennifer R Grandis; Daniel E Johnson
Journal:  Mol Oncol       Date:  2014-04-18       Impact factor: 6.603

8.  Pharmacological inhibition of caspase-8 limits lung tumour outgrowth.

Authors:  Michela Terlizzi; Vincenzo Giuseppe Di Crescenzo; Giuseppe Perillo; Antonio Galderisi; Aldo Pinto; Rosalinda Sorrentino
Journal:  Br J Pharmacol       Date:  2015-06-12       Impact factor: 8.739

9.  Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.

Authors:  Tal Teitz; Madoka Inoue; Marcus B Valentine; Kejin Zhu; Jerold E Rehg; Wei Zhao; David Finkelstein; Yong-Dong Wang; Melissa D Johnson; Christopher Calabrese; Marcelo Rubinstein; Razqallah Hakem; William A Weiss; Jill M Lahti
Journal:  Cancer Res       Date:  2013-03-27       Impact factor: 12.701

Review 10.  Immunogenic cell death and DAMPs in cancer therapy.

Authors:  Dmitri V Krysko; Abhishek D Garg; Agnieszka Kaczmarek; Olga Krysko; Patrizia Agostinis; Peter Vandenabeele
Journal:  Nat Rev Cancer       Date:  2012-11-15       Impact factor: 60.716
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