Literature DB >> 19111059

Convergent formal syntheses of (+/-)-brussonol and (+/-)-abrotanone via an intramolecular Marson-type cyclization.

Dionicio Martinez-Solorio1, Michael P Jennings.   

Abstract

The formal convergent syntheses of both (+/-)-brussonol and (+/-)-abrotanone are reported. The key step involved the diastereoselective capture of an in situ generated oxocarbenium cation via an intramolecular Friedel-Crafts/Marson-type cyclization.

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Year:  2009        PMID： 19111059     DOI： 10.1021/ol802375g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Tandem C-H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (-)-brussonol and (-)-przewalskine E.

Authors:  Zhi-Wei Jiao; Yong-Qiang Tu; Qing Zhang; Wen-Xing Liu; Shu-Yu Zhang; Shao-Hua Wang; Fu-Min Zhang; Sen Jiang
Journal:  Nat Commun       Date:  2015-06-17       Impact factor: 14.919

2.  Synthesis, Structure-Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors.

Authors:  Camila S Barbosa; Anees Ahmad; Sarah El Chamy Maluf; Igor M R Moura; Guilherme E Souza; Giovanna A H Guerra; Roberto R Moraes Barros; Marcos L Gazarini; Anna C C Aguiar; Antonio C B Burtoloso; Rafael V C Guido
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-30
  2 in total

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