OBJECTIVE: We investigated heritability of plasma levels (mass) and activity of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)). MATERIALS AND METHODS: In 54 healthy twins pairs we estimated genetic variance and heritability of Lp-PLA(2) mass and activity using maximum likelihood and least squares methods. We estimated intra-class correlation (ICC) and proportion of additive genetic variance from a model comprising additive genetic influence (A), environmental effect common to cotwins (C) and individually unique environmental (E) influence (ACE) model. RESULTS: Twenty-six twin pairs were monozygotic (MZ) and 28 dizygotic (DZ). The Lp-PLA(2) mass and activity showed a significant correlation (r=0.87, p<0.001) and the mean values were similar in MZ and DZ. ICC estimates of heritability for Lp-PLA(2) were 0.27 (mass) and 0.28 (activity); ACE model-based estimates of heritability were 0.37 (mass) and 0.54 (activity). Heritability estimates were not significant for Lp-PLA(2) mass, but significant for Lp-PLA(2) activity. CONCLUSIONS: These results suggest heritability for activity, but not for mass, in healthy Caucasians.
OBJECTIVE: We investigated heritability of plasma levels (mass) and activity of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)). MATERIALS AND METHODS: In 54 healthy twins pairs we estimated genetic variance and heritability of Lp-PLA(2) mass and activity using maximum likelihood and least squares methods. We estimated intra-class correlation (ICC) and proportion of additive genetic variance from a model comprising additive genetic influence (A), environmental effect common to cotwins (C) and individually unique environmental (E) influence (ACE) model. RESULTS: Twenty-six twin pairs were monozygotic (MZ) and 28 dizygotic (DZ). The Lp-PLA(2) mass and activity showed a significant correlation (r=0.87, p<0.001) and the mean values were similar in MZ and DZ. ICC estimates of heritability for Lp-PLA(2) were 0.27 (mass) and 0.28 (activity); ACE model-based estimates of heritability were 0.37 (mass) and 0.54 (activity). Heritability estimates were not significant for Lp-PLA(2) mass, but significant for Lp-PLA(2) activity. CONCLUSIONS: These results suggest heritability for activity, but not for mass, in healthy Caucasians.
Authors: Parveen K Garg; Robyn L McClelland; Nancy S Jenny; Michael H Criqui; Philip Greenland; Robert S Rosenson; David S Siscovick; Neal Jorgensen; Mary Cushman Journal: Atherosclerosis Date: 2015-05-16 Impact factor: 5.162
Authors: Nathan D Wong; Yanglu Zhao; Ruben G W Quek; Roger S Blumenthal; Matthew J Budoff; Mary Cushman; Parveen Garg; Veit Sandfort; Michael Tsai; J Antonio G Lopez Journal: J Clin Lipidol Date: 2017-06-30 Impact factor: 4.766
Authors: Sunil Suchindran; David Rivedal; John R Guyton; Tom Milledge; Xiaoyi Gao; Ashlee Benjamin; Jennifer Rowell; Geoffrey S Ginsburg; Jeanette J McCarthy Journal: PLoS Genet Date: 2010-04-29 Impact factor: 5.917