OBJECTIVE: The purpose of this study was to compare the prognostic variables and survival of younger (< 50 years) to that of older (> or = 50 years) women with vulvar cancer. STUDY DESIGN: Subjects with invasive squamous cell carcinoma of the vulva were identified from the limited use Surveillance, Epidemiology, and End Results (SEER) Program 1988-2005. Comparisons between younger and older women were accomplished with chi(2) and t-tests. Survival analysis was accomplished with Kaplan-Meier for univariate analysis and Cox proportional hazards model for multivariate analysis. RESULTS: A total of 6965 patients met inclusion criteria, of whom 1345 patients (19.3%) were younger and 5620 patients (80.7%) were older. The 5-year survival was 87.5% for younger women and 52.5% for older women (P < .001). After data were controlled for race, stage, grade, and surgical treatment, older patients had a hazard ratio of 3.9 (95% CI, 3.2-4.7) for death. CONCLUSION: A striking survival difference exists between younger and older women with squamous cell vulvar cancer, which supports the view that etiopathogenesis of this disease may vary between age groups.
OBJECTIVE: The purpose of this study was to compare the prognostic variables and survival of younger (< 50 years) to that of older (> or = 50 years) women with vulvar cancer. STUDY DESIGN: Subjects with invasive squamous cell carcinoma of the vulva were identified from the limited use Surveillance, Epidemiology, and End Results (SEER) Program 1988-2005. Comparisons between younger and older women were accomplished with chi(2) and t-tests. Survival analysis was accomplished with Kaplan-Meier for univariate analysis and Cox proportional hazards model for multivariate analysis. RESULTS: A total of 6965 patients met inclusion criteria, of whom 1345 patients (19.3%) were younger and 5620 patients (80.7%) were older. The 5-year survival was 87.5% for younger women and 52.5% for older women (P < .001). After data were controlled for race, stage, grade, and surgical treatment, older patients had a hazard ratio of 3.9 (95% CI, 3.2-4.7) for death. CONCLUSION: A striking survival difference exists between younger and older women with squamous cell vulvar cancer, which supports the view that etiopathogenesis of this disease may vary between age groups.
Authors: Beatriz de Melo Maia; André Mourão Lavorato-Rocha; Iara Sant'ana Rodrigues; Glauco Baiocchi; Flávia Munhoz Cestari; Monica Maria Stiepcich; Ludmila Thomé Domingues Chinen; Kátia C Carvalho; Fernando Augusto Soares; Rafael Malagoli Rocha Journal: J Transl Med Date: 2012-07-28 Impact factor: 5.531
Authors: I S Rodrigues; A M Lavorato-Rocha; B de M Maia; M M A Stiepcich; F M de Carvalho; G Baiocchi; F A Soares; R M Rocha Journal: Br J Cancer Date: 2013-06-18 Impact factor: 7.640