Literature DB >> 19109876

Peutz-Jeghers syndrome with small intestinal malignancy and cervical carcinoma.

Lian-Jie Li1, Zhi-Qing Wang, Bao-Ping Wu.   

Abstract

We report a case of 30-year-old woman with Peutz-Jeghers syndrome (PJS). Because of small intestinal obstruction, she received the small intestinal polypectomy in 2001, and the pathological diagnosis was Peutz-Jeghers polyp canceration (mucinous adenocarcinoma, infiltrating full-thickness of the intestine). The patient did not feel uncomfortable after 6 mo of chemotherapy and other management. We kept a follow-up study on her and found that she suffered from cervical cancer in 2007, with a pathological diagnosis of cervical adenosquamous carcinoma.The patient presented with typical features of PJS, but without a family history. The PJS accompanied with both small intestinal and cervical malignancies has not been reported so far in the world.

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Year:  2008        PMID: 19109876      PMCID: PMC2778126          DOI: 10.3748/wjg.14.7397

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN: 1007-9327            Impact factor:   5.742


  12 in total

1.  Stem cells, asymmetric division and cancer.

Authors:  Hans Clevers
Journal:  Nat Genet       Date:  2005-10       Impact factor: 38.330

2.  Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.

Authors:  M Jansen; W W J de Leng; A F Baas; H Myoshi; L Mathus-Vliegen; M M Taketo; H Clevers; F M Giardiello; G J A Offerhaus
Journal:  Gut       Date:  2006-01       Impact factor: 23.059

3.  Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.

Authors:  M Miyaki; T Iijima; K Hosono; R Ishii; M Yasuno; T Mori; M Toi; T Hishima; N Shitara; K Tamura; J Utsunomiya; N Kobayashi; T Kuroki; T Iwama
Journal:  Cancer Res       Date:  2000-11-15       Impact factor: 12.701

4.  Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

Authors:  Z J Wang; I Ellis; P Zauber; T Iwama; C Marchese; I Talbot; W H Xue; Z Y Yan; I Tomlinson
Journal:  J Pathol       Date:  1999-05       Impact factor: 7.996

5.  Very high risk of cancer in familial Peutz-Jeghers syndrome.

Authors:  F M Giardiello; J D Brensinger; A C Tersmette; S N Goodman; G M Petersen; S V Booker; M Cruz-Correa; J A Offerhaus
Journal:  Gastroenterology       Date:  2000-12       Impact factor: 22.682

6.  Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.

Authors:  Hiroyuki Miyoshi; Masayuki Nakau; Tomo-o Ishikawa; Michael F Seldin; Masanobu Oshima; Makoto M Taketo
Journal:  Cancer Res       Date:  2002-04-15       Impact factor: 12.701

7.  Female genital tract tumors in Peutz-Jeghers syndrome.

Authors:  K T Chen
Journal:  Hum Pathol       Date:  1986-08       Impact factor: 3.466

8.  Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.

Authors:  S B Gruber; M M Entius; G M Petersen; S J Laken; P A Longo; R Boyer; A M Levin; U J Mujumdar; J M Trent; K W Kinzler; B Vogelstein; S R Hamilton; M H Polymeropoulos; G J Offerhaus; F M Giardiello
Journal:  Cancer Res       Date:  1998-12-01       Impact factor: 12.701

9.  Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.

Authors:  R H Young; W R Welch; G R Dickersin; R E Scully
Journal:  Cancer       Date:  1982-10-01       Impact factor: 6.860

10.  LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.

Authors:  Pekka Katajisto; Kari Vaahtomeri; Niklas Ekman; Eeva Ventelä; Ari Ristimäki; Nabeel Bardeesy; Robert Feil; Ronald A DePinho; Tomi P Mäkelä
Journal:  Nat Genet       Date:  2008-03-02       Impact factor: 38.330

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  1 in total

1.  Metachronous triple cancer associated with Peutz-Jeghers syndrome treated with curative surgery: a case report.

Authors:  Toru Yoshikawa; Tomoyuki Abe; Hironobu Amano; Keiji Hanada; Tomoyuki Minami; Tsuyoshi Kobayashi; Shuji Yonehara; Masahiro Nakahara; Hideki Ohdan; Toshio Noriyuki
Journal:  Surg Case Rep       Date:  2018-08-01
  1 in total

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