Literature DB >> 19109016

Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.

Joseph Guiles1, Xicheng Sun, Ian A Critchley, Urs Ochsner, Ming Tregay, Kim Stone, Jennifer Bertino, Louis Green, Rob Sabin, Frank Dean, H Garry Dallmann, Charles S McHenry, Nebojsa Janjic.   

Abstract

High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described.

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Year:  2008        PMID： 19109016     DOI： 10.1016/j.bmcl.2008.12.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential.

Authors:  H Garry Dallmann; Oliver J Fackelmayer; Guy Tomer; Joe Chen; Anna Wiktor-Becker; Tracey Ferrara; Casey Pope; Marcos T Oliveira; Peter M J Burgers; Laurie S Kaguni; Charles S McHenry
Journal:  Biochemistry       Date:  2010-03-23       Impact factor: 3.162

2.  New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).

Authors:  Carlos J A Ribeiro; Jayakanth Kankanala; Ke Shi; Kayo Kurahashi; Evgeny Kiselev; Azhar Ravji; Yves Pommier; Hideki Aihara; Zhengqiang Wang
Journal:  Eur J Pharm Sci       Date:  2018-03-21       Impact factor: 4.384

3.  2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.

Authors:  Matthew G LaPorte; Dimas José da Paz Lima; Feng Zhang; Malabika Sen; Jennifer R Grandis; Daniel Camarco; Yun Hua; Paul A Johnston; John S Lazo; Lynn O Resnick; Peter Wipf; Donna M Huryn
Journal:  Bioorg Med Chem Lett       Date:  2014-09-15       Impact factor: 2.823

Review 4.  Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target.

Authors:  Andrew Robinson; Rebecca J Causer; Nicholas E Dixon
Journal:  Curr Drug Targets       Date:  2012-03       Impact factor: 3.465

Review 5.  Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities.

Authors:  Elham Jafari; Marzieh Rahmani Khajouei; Farshid Hassanzadeh; Gholam Hossein Hakimelahi; Ghadam Ali Khodarahmi
Journal:  Res Pharm Sci       Date:  2016 Jan-Feb

Review 6.  DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.

Authors:  Erika van Eijk; Bert Wittekoek; Ed J Kuijper; Wiep Klaas Smits
Journal:  J Antimicrob Chemother       Date:  2017-05-01       Impact factor: 5.790

Review 7.  The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.

Authors:  Jon M Kaguni
Journal:  Antibiotics (Basel)       Date:  2018-03-14

Review 8.  Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.

Authors:  Michael A Reiche; Digby F Warner; Valerie Mizrahi
Journal:  Front Mol Biosci       Date:  2017-11-14

9.  Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives.

Authors:  G A Khodarahmi; M Rahmani Khajouei; G H Hakimelahi; D Abedi; E Jafari; F Hassanzadeh
Journal:  Res Pharm Sci       Date:  2012-07

10.  Selective in vivo and in vitro activities of 3,3'-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III.

Authors:  Zheng Hou; Ying Zhou; Jing Li; Xinlei Zhang; Xin Shi; Xiaoyan Xue; Zhi Li; Bo Ma; Yukun Wang; Mingkai Li; Xiaoxing Luo
Journal:  Sci Rep       Date:  2015-09-01       Impact factor: 4.379
  10 in total

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