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Literature DB >> 19108147

Salicylate and liver glutathione.

Abstract

The effects of sodium salicylate, benzoate, gentisate, m- and p-hydroxybenzoates, antipyrine, and 2:4-dinitrophenol on the reduced glutathione concentration of rat liver were determined. An increase in concentration in the male, but not in the female, rats was found after salicylate, benzoate and gentisate; after antipyrine, a comparable increase occurred in the females only. There is a relation, in these compounds, between capacity to increase the concentration of reduced glutathione in the rat liver in one sex and therapeutic activity in rheumatic fever.

Entities: Chemical Disease Species

Year: 1961 PMID： 19108147 PMCID： PMC1481952 DOI： 10.1111/j.1476-5381.1961.tb00311.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

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References

11 in total

Salicylate and liver glutathione.

1. The mechanism of depression of plasma protein bound iodine by 2,4 dinitrophenol.

2. Incorporation of glycine into glutathione and fibrinogen of rats under adrenaline treatment.

3. Salicylates and thyroid function. I. Depression of thyroid function.

4. Salicylates and thyroid function. II. The effect on the thyroid-pituitary interrelation.

5. The determination of glutathione in blood and tissues.

6. Effect of certain hydroxybenzoic acids on the oxygen consumption of Wistar rats.

7. The application of paper partition chromatography to the study of the metabolism of salicylate in the rat.

8. The effect of salicylate and cinchophen on enzymes and metabolic processes.

9. The influence of 2,4-dinitrophenol on plasma protein bound iodine.

10. The relative potencies of some substituted salicylic acids as metabolic stimulants in the intact rat.