Literature DB >> 19108145

Cardiovascular actions of phenoxybenzamine.

B G Benfey.   

Abstract

Phenoxybenzamine increased the force of contraction and rate of the heart and lowered the blood pressure of dogs in pentobarbitone anaesthesia. This was preceded by depression of cardiac contractile force and a rise in blood pressure when phenoxybenzamine was injected following ganglion-blocking drugs or atropine. The positive inotropic and chronotropic and the hypertensive effects of phenoxybenzamine were prevented by pretreatment with reserpine or guanethidine.

Entities:  

Year:  1961        PMID： 19108145      PMCID： PMC1482013          DOI： 10.1111/j.1476-5381.1961.tb00292.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  8 in total

1.  Increased urinary excretion of adrenaline and noradrenaline after phenoxybenzamine.

Authors:  B G BENFEY; G LEDOUX; K I MELVILLE
Journal:  Br J Pharmacol Chemother       Date:  1959-03

2.  The action of antisympathomimetic drugs on the urinary excretion of adrenaline and noradrenaline.

Authors:  B G BENFEY; G LEDOUX; M SEGAL
Journal:  Br J Pharmacol Chemother       Date:  1959-09

3.  Effects of an antihypertensive drug, pentolinium.

Authors:  E HAAS; H GOLDBLATT
Journal:  Am J Physiol       Date:  1959-04

4.  A peripheral action of reserpine.

Authors:  R A MAXWELL; S D ROSS; A J PLUMMER; E B SIGG
Journal:  J Pharmacol Exp Ther       Date:  1957-01       Impact factor: 4.030

5.  The output of sympathetic transmitter from the spleen of the cat.

Authors:  G L BROWN; J S GILLESPIE
Journal:  J Physiol       Date:  1957-08-29       Impact factor: 5.182

6.  [Regitin (preparation C 7337) a new imidazolin derivative with specific sympathicolytic effect].

Authors:  F GROSS; J TRIPOD
Journal:  Schweiz Med Wochenschr       Date:  1951-04-14

7.  Plasma adrenaline and noradrenaline after phenoxybenzamine administration, and during haemorrhagic hypotension, in normal and adrenalectomized dogs.

Authors:  R A MILLAR; E B KEENER; B G BENFEY
Journal:  Br J Pharmacol Chemother       Date:  1959-03

8.  Some effects of dibenzyl-beta-chlorethylamine (dibenamine) on the mammalian heart.

Authors:  G H ACHESON; A FARAH; G N FRENCH
Journal:  J Pharmacol Exp Ther       Date:  1949-12       Impact factor: 4.030
  8 in total
  1 in total

1.  Systemic Alpha1-Adrenoceptor Antagonists and Increased Risk of Open-Angle Glaucoma: A Nationwide Population-Based Cohort Study.

Authors:  Hong-Zin Lin; Tsung-Cheng Hsieh; Jung-Lun Wu; Ming-Shan He; Yuan-Chieh Lee
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-08-03       Impact factor: 4.799
  1 in total

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