BACKGROUND: Swallowing physiology, diet, and patient-reported outcomes were evaluated after induction chemotherapy for oral tongue cancer. METHODS: Fifteen of 23 patients enrolled in a phase II clinical trial of induction chemotherapy followed by surgical resection for oral tongue cancer underwent instrumental and perceptual analysis of speech and swallowing. Oropharyngeal swallow efficiency (OPSE) was calculated. Patient-reported outcomes were collected. We compared pre- and postchemotherapy results. RESULTS: OPSE scores were not significantly different (p > .05) after induction chemotherapy; however, patient-reported swallowing and diet levels were significantly higher (p < .001 and p = .015, respectively). Diet levels improved from soft-chewable to full diet in most patients. Speech intelligibility did not change (p = .328). CONCLUSION: It appears that induction chemotherapy has a negligible effect on speech and swallowing physiology but may provide symptomatic improvement of pain and swallowing after treatment. Further investigations are needed to corroborate these findings.
BACKGROUND: Swallowing physiology, diet, and patient-reported outcomes were evaluated after induction chemotherapy for oral tongue cancer. METHODS: Fifteen of 23 patients enrolled in a phase II clinical trial of induction chemotherapy followed by surgical resection for oral tongue cancer underwent instrumental and perceptual analysis of speech and swallowing. Oropharyngeal swallow efficiency (OPSE) was calculated. Patient-reported outcomes were collected. We compared pre- and postchemotherapy results. RESULTS: OPSE scores were not significantly different (p > .05) after induction chemotherapy; however, patient-reported swallowing and diet levels were significantly higher (p < .001 and p = .015, respectively). Diet levels improved from soft-chewable to full diet in most patients. Speech intelligibility did not change (p = .328). CONCLUSION: It appears that induction chemotherapy has a negligible effect on speech and swallowing physiology but may provide symptomatic improvement of pain and swallowing after treatment. Further investigations are needed to corroborate these findings.
Authors: Barbara Roa Pauloski; Alfred W Rademaker; Jerilyn A Logemann; Fred M S McConnel; Mary Anne Heiser; Salvatore Cardinale; Cathy L Lazarus; Harold Pelzer; David Stein; Quinter Beery Journal: Head Neck Date: 2004-07 Impact factor: 3.147
Authors: Erich M Sturgis; Brian A Moore; Bonnie S Glisson; Merrill S Kies; Dong M Shin; Robert M Byers Journal: Head Neck Date: 2005-09 Impact factor: 3.147
Authors: M Boyd Gillespie; Martin B Brodsky; Terry A Day; Anand K Sharma; Fu-shing Lee; Bonnie Martin-Harris Journal: Arch Otolaryngol Head Neck Surg Date: 2005-07
Authors: Katherine A Hutcheson; Denise A Barringer; David I Rosenthal; Annette H May; Dianna B Roberts; Jan S Lewin Journal: Arch Otolaryngol Head Neck Surg Date: 2008-02
Authors: David L Schwartz; Katherine Hutcheson; Denise Barringer; Susan L Tucker; Merrill Kies; F Christopher Holsinger; K Kian Ang; William H Morrison; David I Rosenthal; Adam S Garden; Lei Dong; Jan S Lewin Journal: Int J Radiat Oncol Biol Phys Date: 2010-06-18 Impact factor: 7.038
Authors: Merrill S Kies; Dowin H Boatright; Guojun Li; George Blumenschein; Adel K El-Naggar; G Brandon Gunn; Jan S Lewin; Ganene D Steinhaus; Erich M Sturgis Journal: Head Neck Date: 2011-10-19 Impact factor: 3.147
Authors: Rebecca L Nund; Nerina A Scarinci; Bena Cartmill; Elizabeth C Ward; Pim Kuipers; Sandro V Porceddu Journal: Dysphagia Date: 2014-08-07 Impact factor: 3.438
Authors: Sylvia L Crowder; Andrew D Frugé; Katherine G Douglas; Yi Tang Chen; Laura Moody; Ashley Delk-Licata; John W Erdman; Molly Black; William R Carroll; Sharon A Spencer; Julie L Locher; Wendy Demark-Wahnefried; Laura Q Rogers; Anna E Arthur Journal: J Acad Nutr Diet Date: 2019-01-17 Impact factor: 4.910
Authors: Katherine A Hutcheson; Jan S Lewin; F Christopher Holsinger; Ganene Steinhaus; Asher Lisec; Denise A Barringer; Heather Y Lin; Sandra Villalobos; Adam S Garden; Vali Papadimitrakopoulou; Merrill S Kies Journal: Head Neck Date: 2013-06-18 Impact factor: 3.147