| Literature DB >> 1910761 |
C J Wilde1, M A Kerr, D T Calvert.
Abstract
Degradation of newly synthesized casein in rat mammary gland perfused in situ was measured by a pulse-chase method using [3H]proline. Casein degradation during secretion was observed in the absence of prolactin, but not with prolactin present. Partial inhibition by chloroquine showed that hormone-dependent degradation occurred intracellularly by a lysosomal mechanism. The study indicates that this post-translational mechanism is a physiological regulator of net casein secretion.Entities:
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Year: 1991 PMID： 1910761 DOI： 10.1113/expphysiol.1991.sp003519
Source DB: PubMed Journal: Exp Physiol ISSN： 0958-0670 Impact factor: 2.969