Literature DB >> 19106781

Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features.

Ignazia Prigione1, Elio Castagnola, Luisa Imberti, Claudio Gambini, Luigi Gradoni, Umberto Dianzani, Ugo Ramenghi, Francesca Giacopelli, Alessandro Moretta, Lorenzo Moretta, Alessandro Plebani, Alain Fischer, Vito Pistoia.   

Abstract

An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRalphabeta, CD4, CD8 cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4 lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

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Year:  2009        PMID： 19106781     DOI： 10.1097/INF.0b013e318185513d

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  5 in total

1.  Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia.

Authors:  Virginia Sheikh; Brian O Porter; Rebecca DerSimonian; Stephen B Kovacs; William L Thompson; Ainhoa Perez-Diez; Alexandra F Freeman; Gregg Roby; JoAnn Mican; Alice Pau; Adam Rupert; Joseph Adelsberger; Jeanette Higgins; Jeffrey S Bourgeois; Stig M R Jensen; David R Morcock; Peter D Burbelo; Leah Osnos; Irina Maric; Ven Natarajan; Therese Croughs; Michael D Yao; Jacob D Estes; Irini Sereti
Journal:  Blood       Date:  2015-12-16       Impact factor: 22.113

2.  Five-year retrospective Italian multicenter study of visceral leishmaniasis treatment.

Authors:  Francesco Di Masi; Tamara Ursini; Maria Donata Iannece; Leonardo Chianura; Francesco Baldasso; Giuseppe Foti; Pietro Di Gregorio; Angelo Casabianca; Nunzio Storaci; Luciano Nigro; Claudia Colomba; Maria Grazia Marazzi; Giovanni Todaro; Giacinta Tordini; Giacomo Zanelli; Giovanni Cenderello; Nicola Acone; Ennio Polilli; Simona Migliore; Paolo Almi; Eligio Pizzigallo; Evangelista Sagnelli; Francesco Mazzotta; Rosario Russo; Lamberto Manzoli; Giustino Parruti
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191

3.  Visceral leishmaniasis complicating idiopathic CD4+ T-cell lymphocytopenia: 2 case reports.

Authors:  Andrew Fox-Lewis; Diana N J Lockwood
Journal:  PLoS Negl Trop Dis       Date:  2017-05-11

Review 4.  Definition of Opportunistic Infections in Immunocompromised Children on the Basis of Etiologies and Clinical Features: A Summary for Practical Purposes.

Authors:  Niccolò Riccardi; Gioacchino Andrea Rotulo; Elio Castagnola
Journal:  Curr Pediatr Rev       Date:  2019

5.  Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti-human herpes virus treatment.

Authors:  María Lilia Díaz Betancourt; Julio César Klínger Hernández; Victoria Eugenia Niño Castaño
Journal:  Colomb Med (Cali)       Date:  2012-12-30
  5 in total

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