OBJECTIVE: To evaluate the significance of multifocality on overall survival (OS) in patients with retroperitoneal sarcoma (RPS) and establish a data-derived, prognostically and therapeutically useful definition of sarcomatosis. SUMMARY BACKGROUND DATA: The incidence, clinical features, and prognostic significance of multifocality in RPS is unknown. No current standardized definition for sarcomatosis is available. METHODS: We conducted a retrospective analysis of 393 patients with primary or recurrent nonmetastatic RPS treated at a comprehensive cancer center between 1996 and 2006. Baseline and treatment variables were compared in patients with unifocal and multifocal disease. A multivariate model was used to evaluate the association of multifocality and OS and identify additional prognostic factors in patients with multifocal disease. RESULTS: The median follow-up time for all patients was 69 months; 79 patients (20%) presented with multifocal disease. The 5-year OS rate was less in the multifocal group compared with the unifocal group (31% vs. 60%, respectively; P < 0.0001). After multivariate analysis, multifocality remained an independent predictor of worse OS {hazard ratio (HR) 1.7 (95% confidence interval (CI), 1.2-2.5); P = 0.004}. Additionally, patients with more tumors had significantly worse prognosis (>7 tumors, HR 2.1 (95% CI, 1.1-3.9); P = 0.03), with a 5-year OS rate of 7%. CONCLUSIONS: Multifocal RPS is associated with worse OS in patients with either primary or recurrent RPS; Patients with >7 tumors had the worst prognosis. This criterion can be used to define sarcomatosis, thereby identifying patients whose survival will ultimately depend on effective systemic therapy.
OBJECTIVE: To evaluate the significance of multifocality on overall survival (OS) in patients with retroperitoneal sarcoma (RPS) and establish a data-derived, prognostically and therapeutically useful definition of sarcomatosis. SUMMARY BACKGROUND DATA: The incidence, clinical features, and prognostic significance of multifocality in RPS is unknown. No current standardized definition for sarcomatosis is available. METHODS: We conducted a retrospective analysis of 393 patients with primary or recurrent nonmetastatic RPS treated at a comprehensive cancer center between 1996 and 2006. Baseline and treatment variables were compared in patients with unifocal and multifocal disease. A multivariate model was used to evaluate the association of multifocality and OS and identify additional prognostic factors in patients with multifocal disease. RESULTS: The median follow-up time for all patients was 69 months; 79 patients (20%) presented with multifocal disease. The 5-year OS rate was less in the multifocal group compared with the unifocal group (31% vs. 60%, respectively; P < 0.0001). After multivariate analysis, multifocality remained an independent predictor of worse OS {hazard ratio (HR) 1.7 (95% confidence interval (CI), 1.2-2.5); P = 0.004}. Additionally, patients with more tumors had significantly worse prognosis (>7 tumors, HR 2.1 (95% CI, 1.1-3.9); P = 0.03), with a 5-year OS rate of 7%. CONCLUSIONS: Multifocal RPS is associated with worse OS in patients with either primary or recurrent RPS; Patients with >7 tumors had the worst prognosis. This criterion can be used to define sarcomatosis, thereby identifying patients whose survival will ultimately depend on effective systemic therapy.
Authors: Thomas Brodowicz; Gabriele Amann; Andreas Leithner; Arpad Sztankay; Franz Kainberger; Wolfgang Eisterer; Bernadette Liegl-Atzwanger; Franz Rachbauer; Thomas Rath; Michael Bergmann; Philipp T Funovics; Ferdinand Ploner; Reinhard Windhager Journal: Wien Klin Wochenschr Date: 2011-10-28 Impact factor: 1.704
Authors: Naruhiko Ikoma; Christina L Roland; Keila E Torres; Yi-Ju Chiang; Wei-Lien Wang; Neeta Somaiah; Gary N Mann; Kelly K Hunt; Janice N Cormier; Barry W Feig Journal: Ann Surg Oncol Date: 2018-03-08 Impact factor: 5.344
Authors: Antonio Chiappa; Emilio Bertani; Gabriella Pravettoni; Andrew Paul Zbar; Diego Foschi; Giuseppe Spinoglio; Bernardo Bonanni; Gianluca Polvani; Federico Ambrogi; Maria Laura Cossu; Carlo Ferrari; Marco Venturino; Cristiano Crosta; Luca Bocciolone; Roberto Biffi Journal: Indian J Surg Date: 2018-01-31 Impact factor: 0.656
Authors: Hari Nathan; Chandrajit P Raut; Katherine Thornton; Joseph M Herman; Nita Ahuja; Richard D Schulick; Michael A Choti; Timothy M Pawlik Journal: Ann Surg Date: 2009-12 Impact factor: 12.969
Authors: M Toulmonde; S Bonvalot; I Ray-Coquard; E Stoeckle; O Riou; N Isambert; E Bompas; N Penel; C Delcambre-Lair; E Saada; A Lecesne; C Le Péchoux; J Y Blay; S Piperno-Neumann; C Chevreau; J O Bay; V Brouste; P Terrier; D Ranchère-Vince; A Neuville; A Italiano Journal: Ann Oncol Date: 2014-02-03 Impact factor: 32.976