CONTEXT: Although previous studies have indicated associations between circulating testosterone (T) or estradiol (E2) concentrations and bone mineral density, the relationship between gonadal steroids and skeletal geometry is not well defined. OBJECTIVE: Our objective was to uncover the relation between circulating T or E2 and proximal femur geometry in a diverse sample of men. DESIGN: We used data on 808 men enrolled in the Boston Area Community Health/Bone Study. Serum concentrations of total and calculated free T and E2 were obtained via early-morning blood sampling. The geometry of the proximal femur at three sites (the narrow neck, intertrochanter, and shaft) was obtained using the Hip Structural Analysis technology. Analyses adjusted for subjects' age, height, total body lean mass and fat mass, and level of physical activity were performed. SETTING: In-home interviews accompanied by subject visits to the General Clinical Research Center at Boston University School of Medicine were performed. STUDY PARTICIPANTS: A randomly selected cohort of men living in Boston, MA (ages 30-79 yr) was included in the study. INTERVENTIONS: These were not applicable. MAIN OUTCOME MEASURES: Bone mineral density and bone outer diameter, cross-sectional area (measuring bone material), and section modulus (an index of bending strength) were calculated. RESULTS: In age-adjusted models, E2 was positively associated with hip strength parameters, whereas T was not. Adjustment for age and other parameters resulted in substantial reductions in, but not complete elimination of, associations between E2 and hip strength parameters. CONCLUSION: Circulating E2 is strongly associated with proximal femur strength, an association that is partially mediated by body composition.
CONTEXT: Although previous studies have indicated associations between circulating testosterone (T) or estradiol (E2) concentrations and bone mineral density, the relationship between gonadal steroids and skeletal geometry is not well defined. OBJECTIVE: Our objective was to uncover the relation between circulating T or E2 and proximal femur geometry in a diverse sample of men. DESIGN: We used data on 808 men enrolled in the Boston Area Community Health/Bone Study. Serum concentrations of total and calculated free T and E2 were obtained via early-morning blood sampling. The geometry of the proximal femur at three sites (the narrow neck, intertrochanter, and shaft) was obtained using the Hip Structural Analysis technology. Analyses adjusted for subjects' age, height, total body lean mass and fat mass, and level of physical activity were performed. SETTING: In-home interviews accompanied by subject visits to the General Clinical Research Center at Boston University School of Medicine were performed. STUDY PARTICIPANTS: A randomly selected cohort of men living in Boston, MA (ages 30-79 yr) was included in the study. INTERVENTIONS: These were not applicable. MAIN OUTCOME MEASURES: Bone mineral density and bone outer diameter, cross-sectional area (measuring bone material), and section modulus (an index of bending strength) were calculated. RESULTS: In age-adjusted models, E2 was positively associated with hip strength parameters, whereas T was not. Adjustment for age and other parameters resulted in substantial reductions in, but not complete elimination of, associations between E2 and hip strength parameters. CONCLUSION: Circulating E2 is strongly associated with proximal femur strength, an association that is partially mediated by body composition.
Authors: Benjamin C C Khoo; Thomas J Beck; Qi-Hong Qiao; Pallav Parakh; Lisa Semanick; Richard L Prince; Kevin P Singer; Roger I Price Journal: Bone Date: 2005-07 Impact factor: 4.398
Authors: L Joseph Melton; Thomas J Beck; Shreyasee Amin; Sundeep Khosla; Sara J Achenbach; Ann L Oberg; B Lawrence Riggs Journal: Osteoporos Int Date: 2005-02-02 Impact factor: 4.507
Authors: S R Cummings; D M Black; M C Nevitt; W Browner; J Cauley; K Ensrud; H K Genant; L Palermo; J Scott; T M Vogt Journal: Lancet Date: 1993-01-09 Impact factor: 79.321
Authors: Alan M Rathbun; Michelle Shardell; Denise Orwig; J Richard Hebel; Gregory E Hicks; Thomas J Beck; Jay Magaziner; Marc C Hochberg Journal: Bone Date: 2016-08-26 Impact factor: 4.398
Authors: Sherri-Ann M Burnett-Bowie; Elizabeth A McKay; Hang Lee; Benjamin Z Leder Journal: J Clin Endocrinol Metab Date: 2009-10-09 Impact factor: 5.958
Authors: Dirk Vanderschueren; Michaël R Laurent; Frank Claessens; Evelien Gielen; Marie K Lagerquist; Liesbeth Vandenput; Anna E Börjesson; Claes Ohlsson Journal: Endocr Rev Date: 2014-09-09 Impact factor: 19.871
Authors: Liesbeth Vandenput; Mattias Lorentzon; Daniel Sundh; Maria E Nilsson; Magnus K Karlsson; Dan Mellström; Claes Ohlsson Journal: J Clin Endocrinol Metab Date: 2014-04-02 Impact factor: 5.958