Literature DB >> 191060

Enzymic hydrolysis of phosphonate esters. Reaction mechanism of intestinal 5'-nucleotide phosphodiesterase.

S J Kelly, L G Butler.   

Abstract

The mechanism of bovine intestinal 5'-nucleotide phosphodiesterase was investigated by determining kinetic constants of systematically varied substrates, with emphasis on esters of phosphonic acids (which have much higer Vmax values than conventional phosphodiester substrates), and by pre-steady-state kinetics using bis(4-nitrophenyl) phosphate as substrate. The results suggest a ping-pong type mechanism, with participation of a covalent enzyme intermediate.

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Year:  1977        PMID： 191060     DOI： 10.1021/bi00625a011

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  9 in total

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2.  Aryl ester prodrugs of cyclic HPMPC. I: Physicochemical characterization and in vitro biological stability.

Authors:  R Oliyai; J P Shaw; C M Sueoka-Lennen; K C Cundy; M N Arimilli; R J Jones; W A Lee
Journal:  Pharm Res       Date:  1999-11       Impact factor: 4.200

3.  Structural Characterization and Directed Evolution of a Novel Acetyl Xylan Esterase Reveals Thermostability Determinants of the Carbohydrate Esterase 7 Family.

Authors:  Fiyinfoluwa A Adesioye; Thulani P Makhalanyane; Surendra Vikram; Bryan T Sewell; Wolf-Dieter Schubert; Don A Cowan
Journal:  Appl Environ Microbiol       Date:  2018-04-02       Impact factor: 4.792

Review 4.  Cellular function and molecular structure of ecto-nucleotidases.

Authors:  Herbert Zimmermann; Matthias Zebisch; Norbert Sträter
Journal:  Purinergic Signal       Date:  2012-05-04       Impact factor: 3.765

5.  Phosphodiesterase activity is a novel property of alkaline phosphatase from osseous plate.

Authors:  A A Rezende; J M Pizauro; P Ciancaglini; F A Leone
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

6.  Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center.

Authors:  Guoqiang Feng; Eric A Tanifum; Harry Adams; Alvan C Hengge; Nicholas H Williams
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419

7.  β-caryophyllene improves sexual performance via modulation of crucial enzymes relevant to erectile dysfunction in rats.

Authors:  Stephen A Adefegha; Ganiyu Oboh; Elijah O Olopade
Journal:  Toxicol Res       Date:  2020-08-20

8.  Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition.

Authors:  Siddig Ibrahim Abdelwahab; Abdelwahab Hassan Mohamed; Osama Yousif Mohamed; Mahjoub Oall; Manal Mohamed Elhassan Taha; Syam Mohan; Mohamed Ibrahim Noordin; Mohd Rais Mustafa; Khalid M Alkharfy
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-13       Impact factor: 2.629

9.  Phenolic extracts and amino acids content from Cucumeropsis mannii naudin and Citrullus lanatus inhibit relevant enzymes of erectile dysfunction in rat's penile tissue.

Authors:  Tajudeen O Jimoh; Adedayo O Ademiluyi; Ganiyu Oboh; Aline A Boligon
Journal:  Biochem Biophys Rep       Date:  2017-08-16
  9 in total

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