| Literature DB >> 19105659 |
Yingming Wu1, Jingfeng Zhao, Jingbo Chen, Chengxue Pan, Liang Li, Hongbin Zhang.
Abstract
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.Entities:
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Year: 2009 PMID： 19105659 DOI： 10.1021/ol8026208
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005