| Literature DB >> 19103485 |
Christiane Contino-Pépin1, Audrey Parat, Sandrine Périno, Christine Lenoir, Michel Vidal, Hervé Galons, Stephen Karlik, Bernard Pucci.
Abstract
The present work deals with the synthesis of a new series of thalidomide derivatives for therapeutic applications. These compounds were evaluated in vitro on a human endothelial cell line EA.hy926 for their antiproliferative potential and in vivo on an experimental animal multiple sclerosis model called EAE as angiogenesis inhibitors. The preliminary results obtained on EAE assays seem to validate that anti-angiogenesis compounds could be promising tools for the treatment of MS.Entities:
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Year: 2008 PMID： 19103485 DOI： 10.1016/j.bmcl.2008.11.118
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823