AIMS: To assess the pathological findings in lobectomy specimens, to correlate them with smoking history and postoperative course and to compare the findings with those in smoking-related interstitial lung disease. METHODS AND RESULTS: Patients who had undergone lobectomy for lung cancer were reviewed. Subjects included 230 non-smokers and 587 smokers, of whom 572 had a known smoking index (SI). They were classified into mild, moderate and heavy smokers. Centrilobular emphysema (CLE), respiratory bronchiolitis, airspace enlargement with fibrosis (AEF), the presence of foci resembling usual interstitial pneumonia pattern (UIP/P) and the rate of postoperative respiratory failure were assessed. The incidence of AEF was 6.5% in mild smokers, and 17.7% in moderate smokers (P < 0.01) with lower lobe predominance. There were significant correlations (P < 0.01) between AEF and CLE and AEF and UIP/P. The rate of respiratory failure after lobectomy was 6%, and 10% in patients having UIP/P with or without AEF, but was not seen in patients with AEF alone (P < 0.01). CONCLUSIONS: AEF is an important smoking-related change in the lung that appears to correlate with the smoking history, and its distinction from UIP/P may be important.
AIMS: To assess the pathological findings in lobectomy specimens, to correlate them with smoking history and postoperative course and to compare the findings with those in smoking-related interstitial lung disease. METHODS AND RESULTS:Patients who had undergone lobectomy for lung cancer were reviewed. Subjects included 230 non-smokers and 587 smokers, of whom 572 had a known smoking index (SI). They were classified into mild, moderate and heavy smokers. Centrilobular emphysema (CLE), respiratory bronchiolitis, airspace enlargement with fibrosis (AEF), the presence of foci resembling usual interstitial pneumonia pattern (UIP/P) and the rate of postoperative respiratory failure were assessed. The incidence of AEF was 6.5% in mild smokers, and 17.7% in moderate smokers (P < 0.01) with lower lobe predominance. There were significant correlations (P < 0.01) between AEF and CLE and AEF and UIP/P. The rate of respiratory failure after lobectomy was 6%, and 10% in patients having UIP/P with or without AEF, but was not seen in patients with AEF alone (P < 0.01). CONCLUSIONS: AEF is an important smoking-related change in the lung that appears to correlate with the smoking history, and its distinction from UIP/P may be important.
Authors: Kevin R Flaherty; Charlene Fell; Marie-Christine Aubry; Kevin Brown; Thomas Colby; Ulrich Costabel; Teri J Franks; Barry H Gross; David M Hansell; Ella Kazerooni; Dong Soon Kim; Talmadge E King; Masanori Kitachi; David Lynch; Jeff Myers; Sonoko Nagai; Andrew G Nicholson; Venerino Poletti; Ganesh Raghu; Moises Selman; Galen Toews; William Travis; Athol U Wells; Robert Vassallo; Fernando J Martinez Journal: Eur Respir J Date: 2014-07-25 Impact factor: 16.671
Authors: Hiroto Hatabu; Gary M Hunninghake; Luca Richeldi; Kevin K Brown; Athol U Wells; Martine Remy-Jardin; Johny Verschakelen; Andrew G Nicholson; Mary B Beasley; David C Christiani; Raúl San José Estépar; Joon Beom Seo; Takeshi Johkoh; Nicola Sverzellati; Christopher J Ryerson; R Graham Barr; Jin Mo Goo; John H M Austin; Charles A Powell; Kyung Soo Lee; Yoshikazu Inoue; David A Lynch Journal: Lancet Respir Med Date: 2020-07 Impact factor: 30.700
Authors: Catherine Vaughan; Lathika Mohanraj; Shilpa Singh; Catherine I Dumur; Mahesh Ramamoorthy; Carleton T Garrett; Brad Windle; W Andrew Yeudall; Sumitra Deb; Swati Palit Deb Journal: Genes Cancer Date: 2011-10
Authors: Stijn E Verleden; Naoya Tanabe; John E McDonough; Dragoş M Vasilescu; Feng Xu; Wim A Wuyts; Davide Piloni; Laurens De Sadeleer; Stijn Willems; Cindy Mai; Jeroen Hostens; Joel D Cooper; Erik K Verbeken; Johny Verschakelen; Craig J Galban; Dirk E Van Raemdonck; Thomas V Colby; Marc Decramer; Geert M Verleden; Naftali Kaminski; Tillie-Louise Hackett; Bart M Vanaudenaerde; James C Hogg Journal: Lancet Respir Med Date: 2020-02-13 Impact factor: 30.700