Chiral guanidine catalyzed enantioselective reactions.

Chiral guanidine catalysts share common characteristics such as high pK(a) values and dual hydrogen-bonding modes of activation, and high catalytic activities and enantioselectivities can often be achieved. The utilization of guanidines as catalysts has been growing at a steady pace. In the past few years, it has attracted tremendous attention through several landmark achievements. This article highlights the development of chiral guanidine catalysis in asymmetric synthesis.